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. 2024 Feb;18(1):110-118.
doi: 10.4162/nrp.2024.18.1.110. Epub 2024 Jan 16.

Positive effects of anthocyanin-rich mulberry milk on mental health problems in the working population: an open-label study

Poonsri Rangseekajee  1   2   3 , Nawanant Piyavhatkul  1   2   3 , Jintanaporn Wattanathorn  1   3 , Wipawee Thukham-Mee  1   3 , Pongsatorn Paholpak  1   2   3
Affiliations

Positive effects of anthocyanin-rich mulberry milk on mental health problems in the working population: an open-label study

Poonsri Rangseekajee et al. Nutr Res Pract. 2024 Feb.

Abstract

Background/objectives: Depression and anxiety are common mental health problems. Anthocyanins from berries might have an inhibitory effect on monoamine oxidase (MAO) enzymes and alleviate various mood and anxiety symptoms. This study examined the effects of a daily supplement of an anthocyanin-rich product on mental health problems.

Subjects/methods: This study was a secondary analysis from a randomized, 6-week, open-label trial in 300 healthy participants aged 18-60 years who consumed 1 or 2 servings of anthocyanin-rich mulberry milk daily. The General Health Questionnaire-28 (GHQ-28) and Hospital Anxiety and Depression Scale (HADS) were used to monitor mental health problems. In addition, the saliva activity levels of MAO-A, MAO-B, and cortisol were examined at the baseline and after 6 weeks.

Results: The total scores of the GHQ-28 and HADS and all their subscales decreased in both groups (all P < 0.05). The cortisol, MAO-A, and MAO-B activities decreased significantly (all P <0.05), but there were no significant differences between the groups (all P > 0.05). Significant correlations were noted between the decreased activity level of MAO-A enzyme and decreased scores from the GHQ-28 somatic subscale and the HADS depression subscale (all P < 0.05).

Conclusions: Daily consumption of anthocyanin-rich mulberry milk possibly improves mental health problems by reducing depressive and anxiety symptoms in the working population. The suppression of MAO-A activity is a possible underlying mechanism.

Trial registration: Thai Clinical Trial Registration: #TCTR20201031002.

Keywords: Depression; anthocyanins; anxiety; mulberry.

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Conflict of interest statement

Conflict of Interest: The authors declare no potential conflicts of interests.

Figures

Fig. 1
Fig. 1. Schematic diagram of the study.
GHQ-28, General Health Questionnaire-28; HADS, Hospital Anxiety and Depression Scale; MAO, monoamine oxidase.
See this image and copyright information in PMC

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References

    1. Liu CH, Zhang E, Wong GTF, Hyun S, Hahm HC. Factors associated with depression, anxiety, and PTSD symptomatology during the COVID-19 pandemic: clinical implications for U.S. young adult mental health. Psychiatry Res. 2020;290:113172. - PMC - PubMed
    1. Tseilikman V, Dremencov E, Tseilikman O, Pavlovicova M, Lacinova L, Jezova D. Role of glucocorticoid- and monoamine-metabolizing enzymes in stress-related psychopathological processes. Stress. 2020;23:1–12. - PubMed
    1. Barros D, Amaral OB, Izquierdo I, Geracitano L, do Carmo Bassols Raseira M, Henriques AT, Ramirez MR. Behavioral and genoprotective effects of Vaccinium berries intake in mice. Pharmacol Biochem Behav. 2006;84:229–234. - PubMed
    1. Cásedas G, Les F, Gómez-Serranillos MP, Smith C, López V. Anthocyanin profile, antioxidant activity and enzyme inhibiting properties of blueberry and cranberry juices: a comparative study. Food Funct. 2017;8:4187–4193. - PubMed
    1. Kaewkaen P, Tong-Un T, Wattanathorn J, Muchimapura S, Kaewrueng W, Wongcharoenwanakit S. Mulberry fruit extract protects against memory impairment and hippocampal damage in animal model of vascular dementia. Evid Based Complement Alternat Med. 2012;2012:263520. - PMC - PubMed