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Review
. 2023 Nov 24;33(1):1-7.
doi: 10.1055/s-0043-1777258. eCollection 2024 Feb.

Current Evidence and Future Directions of Omega-3 Supplementation and Cardiovascular Disease Risk

Bambang Dwiputra  1 , Anwar Santoso  1 , Budhi Setianto Purwowiyoto  1 , Basuni Radi  1 , Bashar Adi Wahyu Pandhita  1 , Serlie Fatrin  1 , Ade Meidian Ambari  1
Affiliations
Review

Current Evidence and Future Directions of Omega-3 Supplementation and Cardiovascular Disease Risk

Bambang Dwiputra et al. Int J Angiol. .

Abstract

Omega-3 supplementation has a controversial role in the secondary prevention of cardiovascular diseases. Despite large clinical trials published over the years, the evidence of omega-3 in preventing cardiovascular diseases, especially coronary heart disease, is still inconclusive. However, recent clinical trials using higher dose of omega-3 or highly purified esters of omega-3 shows promising result, with reduction in cardiovascular death and incidence of cardiovascular disease. This review aims to summarize the possible mechanism of omega-3 in preventing cardiovascular disease and future directions of research regarding the benefit of omega-3 in cardiovascular disease.

Keywords: atherosclerosis; cardiovascular disease; eicosapentaenoic acid; fatty acid; omega-3; prevention.

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Conflict of interest statement

Conflict of Interest None declared.

Figures

Fig. 1
Fig. 1
Molecular mechanism of omega-3 in atherosclerosis.
See this image and copyright information in PMC

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