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. 2024 Feb 2;62(8):1643-1648.
doi: 10.1515/cclm-2023-1308. Print 2024 Jul 26.

Fetal chronic hypoxia does not affect urinary presepsin levels in newborns at birth

Ebe D'Adamo  1 , Gabriella Levantini  1 , Michela Librandi  1 , Valentina Botondi  1 , Laura Di Ricco  1 , Sara De Sanctis  1 , Cynzia Spagnuolo  1 , Francesca Gazzolo  2 , Danilo Aw Gavilanes  3 , Patrizia Di Gregorio  4 , Jessica Di Monte  4 , Maria Chiara Strozzi  5 , Antonio Maconi  6 , Maurizio Cassinari  7 , Roberta Libener  7 , Diego Gazzolo  1
Affiliations

Fetal chronic hypoxia does not affect urinary presepsin levels in newborns at birth

Ebe D'Adamo et al. Clin Chem Lab Med. .

Abstract

Objectives: Early sepsis detection and diagnosis still constitutes an open issue since the accuracy of standard-of care parameters is biased by a series of perinatal factors including hypoxia. Therefore, we aimed at investigating the effect of fetal chronic hypoxia insult on urine levels of a promising new marker of sepsis, namely presepsin (P-SEP).

Methods: We conducted a prospective case-control study in 22 cases of early-intrauterine growth restriction (E-IUGR) compared with 22 small-for-gestational-age (SGA) newborns and 66 healthy controls. P-SEP urine samples were collected over the first 72 h from birth. Blood culture and C-reactive protein (CRP) blood levels were measured in E-IUGR and SGA infants. Perinatal standard monitoring parameters and main outcomes were also recorded.

Results: No significant urinary P-SEP differences (p>0.05, for all) were observed among studied groups. Moreover, no significant correlations (p>0.05, for both) between urinary P-SEP and blood CRP levels in both E-IUGR and SGA groups (R=0.08; R=0.07, respectively) were observed.

Conclusions: The present results showing the lack of influence of fetal chronic hypoxia on urinary P-SEP levels offer additional data to hypothesize the possible use of urinary P-SEP measurement in neonates in daily clinical practice. Further multicenter prospective data are needed, including infants with early-onset sepsis.

Keywords: hypoxia; intrauterine growth retardation; newborns; presepsin.

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