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Review
. 2024 May;59(5):1165-1174.
doi: 10.1002/ppul.26905. Epub 2024 Feb 14.

Fibrotic lung diseases in children

Birce Sunman  1 , Nural Kiper  1
Affiliations
Review

Fibrotic lung diseases in children

Birce Sunman et al. Pediatr Pulmonol. 2024 May.

Abstract

In children, pulmonary fibrosis (PF) is an extremely unusual entity that can be observed in some types of interstitial lung disease (ILD). Defining whether ILD is accompanied by PF is important for targeted therapy. Algorithm for the diagnosis of PF in children is not clearly established. Besides, the clinical, radiological, and histological definitions commonly used to diagnose particularly the cases of idiopathic PF in adult patients, is not applicable to pediatric cases. However, a few studies conducted in children offer good exemplary diagnostic approach to fibrosing ILD. Thorax high resonance computed tomography and/or lung biopsy scanning can provide valuable information about PF. Another issue that has not been clearly established is when to start antifibrotic treatment in pediatric patients with PF. The objective of this current review is to provide a comprehensive overview of pediatric PF by drawing upon adult research, particularly focusing on the areas of uncertainty.

Keywords: antifibrotic; children; interstitial lung disease; nintedanib; pirfenidone; pulmonary fibrosis.

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References

REFERENCES

    1. DeBoer EM, Liptzin DR, Humphries SM, et al. Ground glass and fibrotic change in children with surfactant protein C dysfunction mutations. Pediatr Pulmonol. 2021;56(7):2223‐2231.
    1. Kornum JB, Christensen S, Grijota M, et al. The incidence of interstitial lung disease 1995‐2005: a Danish nationwide population‐based study. BMC Pulm Med. 2008;8:24.
    1. Clement A, Nathan N, Epaud R, Fauroux B, Corvol H. Interstitial lung diseases in children. Orphanet J Rare Dis. 2010;5:22.
    1. Bhalla D, Jana M, Naranje P, Bhalla AS, Kabra SK. Fibrosing interstitial lung disease in children: an HRCT‐based analysis. Indian J Pediatr. 2023;90(2):153‐159.
    1. Ionescu MD, Popescu NA, Stănescu D, et al. The challenging diagnosis of interstitial lung disease in Children‐One case report and literature review. J Clin Med. 2022;11(22):6736.

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