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. 2024 Feb 15;390(7):669-671.
doi: 10.1056/NEJMc2312556.

HIV-1 Remission after Allogeneic Hematopoietic-Cell Transplantation

Jana K Dickter  1 , Ahmed Aribi  1 , Angelo A Cardoso  1 , Sara Gianella  1 , Ketevan Gendzekhadze  1 , Shirley Li  1 , Ye Feng  1 , Antoine Chaillon  2 , Gregory M Laird  3 , Diana L Browning  4 , Justine A Ross  4 , Deepa D Nanayakkara  4 , Alfredo Puing  4 , Rodica Stan  4 , Lily L Lai  4 , Sue Chang  4 , Trilokesh D Kidambi  4 , Sandra Thomas  4 , Monzr M Al Malki  4 , Ryo Nakamura  4 , Joseph Alvarnas  4 , Randy A Taplitz  4 , Sanjeet S Dadwal  4 , Stephen J Forman  4 , John A Zaia  4
Affiliations

HIV-1 Remission after Allogeneic Hematopoietic-Cell Transplantation

Jana K Dickter et al. N Engl J Med. .
No abstract available

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Figures

Figure 1.
Figure 1.. Patient’s Course of Treatment and Immunologic Studies.
Panel A shows the patient’s CD4 counts (orange line) and HIV RNA (blue dots) over time relative to treatment with induction chemotherapy, the course of hematopoietic-cell transplantation (HCT) for the treatment of acute myelogenous leukemia (AML), and interruption of antiretroviral treatment (ART). Also shown is HIV-1 reservoir analysis by droplet digital polymerase chain reaction on the patient’s cellular DNA and RNA at indicated time points in samples of peripheral blood mononuclear cells (PBMCs) (Panel B) and biopsy samples of rectal tissue (Panel C). Data show the number of copies per 1 million CD4 T cells. Panel D shows the HIV challenge at 12 months after treatment interruption. CD8-depleted PMBCs were challenged with HIV BaL (R5), NL4-3 (X4), and 89.6 (R5X4) strains, and levels of HIV p24 were measured by enzyme-linked immunosorbent assay in culture supernatants in duplicate. Panel E shows T-cell responses to stimulation by cytomegalovirus (CMV) and HIV peptide pools with the use of activation-induced marker (AIM) flow assay at 12 months after treatment interruption. PBMC samples were cultured with the respective peptide pools for 20 hours; viral responsive CD4 T cells were defined according to CD25 and OX-40 expression, and CD8 T cells were defined according to CD25 and CD137 expression. COH Pt denotes City of Hope study patient, DC’d discontinued, DTG dolutegravir, FTC emtricitabine, Gag group-specific antigen, HD healthy donor, RIC reduced-intensity conditioning, RNA msTat/Rev multiply spliced RNA encoding for transactivation of transcription (Tat) and regulator of expression of virion proteins (Rev), TAF tenofovir alafenamide, and usGag unspliced RNA encoding Gag.
See this image and copyright information in PMC

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