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Comment
. 2024 Feb 13;57(2):193-195.
doi: 10.1016/j.immuni.2024.01.015.

Immunity as biophysics at the surface of a T cell

Daniel S Chen  1
Affiliations
Free article
Comment

Immunity as biophysics at the surface of a T cell

Daniel S Chen. Immunity. .
Free article

Abstract

Different antibodies can bind to the same targets on the surface of immune cells with opposite biologic effects. These effects-agonism, antagonism, or partial agonism-are so poorly understood that drug developers must screen antibodies for relevant desired characteristics. In this issue of Immunity, Lippert et al. define molecular mechanisms that dictate antibody behavior, ushering in an era of directed antibody design.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

Comment on

  • Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases.
    Lippert AH, Paluch C, Gaglioni M, Vuong MT, McColl J, Jenkins E, Fellermeyer M, Clarke J, Sharma S, Moreira da Silva S, Akkaya B, Anzilotti C, Morgan SH, Jessup CF, Körbel M, Gileadi U, Leitner J, Knox R, Chirifu M, Huo J, Yu S, Ashman N, Lui Y, Wilkinson I, Attfield KE, Fugger L, Robertson NJ, Lynch CJ, Murray L, Steinberger P, Santos AM, Lee SF, Cornall RJ, Klenerman D, Davis SJ. Lippert AH, et al. Immunity. 2024 Feb 13;57(2):256-270.e10. doi: 10.1016/j.immuni.2024.01.007. Immunity. 2024. PMID: 38354703

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