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Case Reports
. 2024 Feb 13;57(2):203-205.
doi: 10.1016/j.immuni.2024.01.014.

A case of too much sugar: Lung DCs flummoxed by flu

Ying Xi  1 , Tiffany Horng  2
Affiliations
Free article
Case Reports

A case of too much sugar: Lung DCs flummoxed by flu

Ying Xi et al. Immunity. .
Free article

Abstract

Diabetes is known to increase susceptibility to respiratory infections, but the underlying basis remains elusive. In a recent study in Nature, Nobs et al. showed that hyperglycemia impinges on the histone acetylation landscape to impair the ability of lung dendritic cells to prime adaptive immunity.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Lung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes.
    Nobs SP, Kolodziejczyk AA, Adler L, Horesh N, Botscharnikow C, Herzog E, Mohapatra G, Hejndorf S, Hodgetts RJ, Spivak I, Schorr L, Fluhr L, Kviatcovsky D, Zacharia A, Njuki S, Barasch D, Stettner N, Dori-Bachash M, Harmelin A, Brandis A, Mehlman T, Erez A, He Y, Ferrini S, Puschhof J, Shapiro H, Kopf M, Moussaieff A, Abdeen SK, Elinav E. Nobs SP, et al. Nature. 2023 Dec;624(7992):645-652. doi: 10.1038/s41586-023-06803-0. Epub 2023 Dec 13. Nature. 2023. PMID: 38093014 Free PMC article.

References

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