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. 2024 Sep-Oct;14(5):457-463.
doi: 10.1016/j.prro.2023.12.014. Epub 2024 Feb 12.

Handling Patient Emergencies During Radiopharmaceutical Therapy

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Handling Patient Emergencies During Radiopharmaceutical Therapy

Nichole M Maughan et al. Pract Radiat Oncol. 2024 Sep-Oct.

Abstract

Purpose: Radiopharmaceutical therapy (RPT) is a rapidly growing treatment modality. Though uncommon, patients may experience complications during their RPT treatment, which may trigger a rapid response from the hospital team. However, members of this team are typically not familiar with precautions for radiation safety. During these events, it is important to prioritize the patient's health over all else. There are some practices that can help minimize the risk of radiation contamination spread and exposure to staff while tending to the patient.

Methods and materials: We formed a team to develop a standard protocol for handling patient emergencies during RPT treatment. This team consisted of an authorized user, radiation safety officer, medical physicist, nurse, RPT administration staff, and a quality/safety coordinator. The focus for developing this standardized protocol for RPT patient emergencies was 3-fold: (1) stabilize the patient; (2) reduce radiation exposure to staff; and (3) limit the spread of radiation contamination.

Results: We modified our hospital's existing rapid response protocol to account for the additional staff and tasks needed to accomplish all 3 of these goals. Each team member was assigned specific responsibilities, which include serving as a gatekeeper to restrict traffic, managing the crash cart, performing chest compressions, timing chest compressions, documenting the situation, and monitoring/managing radiation safety in the area. We developed a small, easy-to-read card for rapid response staff to read while they are en route to the area so they can be aware of and prepare for the unique circumstances that RPT treatments present.

Conclusions: Though rapid response events with RPT patients are uncommon, it is important to have a standardized protocol for how to handle these situations beforehand rather than improvise in the moment. We have provided an example of how our team adapted our hospital's current rapid response protocol to accommodate RPT patients.

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Conflict of interest statement

Disclosures NMM received travel funds from AAPM for serving as faculty at the AAPM Summer School 2023; JZ serves in leadership roles in the AAPM educational committees and receives complimentary registration to the ASTRO annual meeting for presenting at the ASTRO Master Class on Radiopharmaceutical Therapies; BCB receives consulting fees for Varian, Boston Scientific, Myovant, and Galera Therapeutics/Regeneron, received speaking honoraria from Varian, and used to serve on the board of National Association for Proton Therapy; AM received consulting fees from Novartis; HK has received consulting fees for Novartis; no other authors have anything to disclose.

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