Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Feb 14;17(2):e258038.
doi: 10.1136/bcr-2023-258038.

Ovarian teratoma-associated anti-NMDA receptor encephalitis with severe features

Antanina Voit  1 , Ashley Graziano  2 , Andrew Schomer  2 , Danny Theodore  2
Affiliations
Case Reports

Ovarian teratoma-associated anti-NMDA receptor encephalitis with severe features

Antanina Voit et al. BMJ Case Rep. .

Abstract

Anti-N-methyl-D-aspartame receptor (NMDAR) encephalitis is an uncommon clinical entity for the general intensivist or neurologist. Diagnosis can be made by the presence of cerebrospinal fluid IgG antibody against the GluNR1 and GluNR2 subunits of the NMDAR. We present a case of anti-NMDAR encephalitis in a young woman with an ovarian teratoma treated with surgical resection and multiple immunomodulatory therapies.

Keywords: Adult intensive care; Epilepsy and seizures; Neurological injury.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

References

    1. Sarosh I, Katarzyna B, Patrick W, et al. N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain 2010:1655–67. 10.1093/brain/awq113 - DOI - PMC - PubMed
    1. Thaler FS, Zimmermann L, Kammermeier S, et al. Rituximab Treatment and Long-term Outcome of Patients With Autoimmune Encephalitis: Real-world Evidence From the GENERATE Registry. Neurol Neuroimmunol Neuroinflamm 2021;8:e1088. 10.1212/NXI.0000000000001088 - DOI - PMC - PubMed
    1. Bost C, Chanson E, Picard G, et al. Malignant tumors in autoimmune encephalitis with anti-NMDA receptor antibodies. J Neurol 2018;265:2190–200. 10.1007/s00415-018-8970-0 - DOI - PubMed
    1. Dalmau J, Armangué T, Planagumà J, et al. An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models. Lancet Neurol 2019;18:1045–57. 10.1016/S1474-4422(19)30244-3 - DOI - PubMed
    1. Cho E, Park J-Y. Emerging roles of 14-3-3γ in the brain disorder. BMB Rep 2020;53:500–11. 10.5483/BMBRep.2020.53.10.158 - DOI - PMC - PubMed

Publication types

MeSH terms

Substances

Supplementary concepts

LinkOut - more resources