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Comment
. 2024 Jan-Dec;16(1):2316927.
doi: 10.1080/19490976.2024.2316927. Epub 2024 Feb 14.

From a hunger-regulating hormone to an antimicrobial peptide: gastrointestinal derived circulating endocrine hormone-peptide YY exerts exocrine antimicrobial effects against selective gut microbiota

Affiliations
Comment

From a hunger-regulating hormone to an antimicrobial peptide: gastrointestinal derived circulating endocrine hormone-peptide YY exerts exocrine antimicrobial effects against selective gut microbiota

Yuchen Xiao et al. Gut Microbes. 2024 Jan-Dec.
No abstract available

Keywords: C. albicans; GI tract; PYY; Paneth cell; antimicrobial peptide; gut microbiota.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Mechanism of PYY release from paneth cells (PCs), its regulation by fungal symbionts, and their potential implications in inflammatory bowel disease.
Figure 2.
Figure 2.
The gut-brain hormone axis: bidirectional hormone signaling between the gut and central nervous system.

Comment on

References

    1. Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG. et al. Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism. Science. 2023;381(6657):502–6. doi:10.1126/science.abq3178. - DOI - PMC - PubMed
    1. Hansen HH, Grønlund RV, Baader-Pagler T, Haebel P, Tammen H, Larsen LK, Jelsing J, Vrang N, Klein T. Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice. Sci Rep. 2021;11(1):8060. doi:10.1038/s41598-021-87539-7. - DOI - PMC - PubMed
    1. Bliss ES, Whiteside E. The gut-brain axis, the human gut microbiota and their integration in the development of obesity. Front Physiol. 2018;9:900. doi:10.3389/fphys.2018.00900. - DOI - PMC - PubMed
    1. Wang SL, Shao B-Z, Zhao S-B, Fang J, Gu L, Miao C-Y, Li Z-S, Bai Y. Impact of paneth cell autophagy on inflammatory bowel disease. Front Immunol. 2018;9:693. doi:10.3389/fimmu.2018.00693. - DOI - PMC - PubMed
    1. Adolph TE, Tomczak MF, Niederreiter L, Ko H-J, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S. et al. Paneth cells as a site of origin for intestinal inflammation. Nature. 2013;503(7475):272–6. doi:10.1038/nature12599. - DOI - PMC - PubMed

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