Discovery of Enzyme Inhibitors from Mangrove Sediment Derived Fungus Trichoderma harzianum SCSIO 41051
- PMID: 38356321
- DOI: 10.1002/cbdv.202400070
Discovery of Enzyme Inhibitors from Mangrove Sediment Derived Fungus Trichoderma harzianum SCSIO 41051
Abstract
One new fatty acid derivative, (2E,4E)-6,7-dihydroxy-2-methylocta-2,4-dienoic acid (1), and 16 known compounds (2-17) were isolated from the mangrove sediment derived fungus Trichoderma harzianum SCSIO 41051. Their structures were established by spectroscopic methods, computational ECD, and Mo2(OAc)4-induced ECD experiment. All the compounds were evaluated for their acetylcholinesterase (AChE) and pancreatic lipase (PL) inhibition. Compounds 9 and 14 exhibited moderate AChE inhibitory activities with IC50 values of 2.49 and 2.92 μM, respectively, which compounds 8 and 9 displayed moderate inhibition on PL with IC50 value of 2.30 and 2.34 μM, respectively.
Keywords: Trichoderma harzianum; enzyme inhibitory; mangrove sediment derived fungus.
© 2024 Wiley‐VHCA AG, Zurich, Switzerland.
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- 2023B1111050008/Key-Area Research and Development Program of Guangdong Province
- GDNRC[2022]35/Special Funds for Promoting Economic Development
- GDOE[2019]A28/Special Funds for Promoting Economic Development
- 2021A1515011711/Natural Science Foundation of Guangdong Province
- 2021A1515410002/Natural Science Foundation of Guangdong Province
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