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. 2024 Jan-Feb;40(3Part-II):326-331.
doi: 10.12669/pjms.40.3.8467.

Correlation between serum microRNA-122 and VEGF expression and pregnancy outcome in gestational diabetes mellitus patients

Hongmei He  1 , Yi Wang  2 , Haijiao Wang  3 , Yulan Ma  4 , Pan Zhang  5
Affiliations

Correlation between serum microRNA-122 and VEGF expression and pregnancy outcome in gestational diabetes mellitus patients

Hongmei He et al. Pak J Med Sci. 2024 Jan-Feb.

Abstract

Objective: Gestational diabetes mellitus (GDM) seriously influences the health of mothers and babies, and there are still no effective early diagnostic markers. Therefore, our study planned to probe the correlation between serum microRNA-122 and VEGF expression and pregnancy outcome in GDM patients.

Methods: This was a retrospective study of the correlation between serum microRNA-122 and vascular endothelial growth factor (VEGF) expression and pregnancy outcome in GDM patients. Sixty GDM patients admitted to the Fourth Hospital of Shijiazhuang from January 2021 to October 2022 were included in the research group (RG), and another 60 healthy pregnant women were included in the control group (CG). Serum miR-122 and VEGF levels were quantified using quantitative real-time polymerase chain reaction. The value of miR-122 and VEGF in predicting adverse pregnancy outcomes was analyzed by receiver operating characteristic curve.

Results: Serum miR-122 and VEGF levels in the RG were higher relative to the CG. The total occurrence of adverse pregnancy outcomes in the RG was higher relative to the CG (P<0.05). Serum miR-122 together with VEGF levels in the poor outcome group was higher relative to the good outcome group (P<0.05). ROC analysis revealed that miR-122 and VEGF could be used to predict adverse pregnancy outcome (P<0.0001). The area under the curve of miR-122 was 0.860, 95% confidence interval (CI) =0.793-0.926, and the area under the curve of VEGF was 0.780, 95% CI =0.694-0.866. Serum levels of miR-122, VEGF were positively related with abortion, preterm delivery, low birth weight infants, macrogenesis infants, and fetal development abnormalities (P<0.001).

Conclusion: The higher serum miR-122 and VEGF levels in GDM patients with satisfactory blood glucose control, the greater the probability of adverse pregnancy outcome, which should be paid attention to by clinicians.

Keywords: Gestational diabetes mellitus; Pregnancy outcome; VEGF; miR-122.

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Conflict of interest statement

Conflicts of interest: None.

Figures

Fig.1
Fig.1
Serum miR-122 and VEGF levels in both groups. *P<0.05.
Fig.2
Fig.2
Serum miR-122 and VEGF levels in patients with different pregnancy outcomes in the research group. *P<0.05.
Fig.3
Fig.3
ROC analysis of miR-122 and VEGF in predicting adverse pregnancy outcomes.
See this image and copyright information in PMC

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References

    1. Szmuilowicz ED, Josefson JL, Metzger BE. Gestational Diabetes Mellitus. Endocrinol Metab Clin North Am. 2019;48(3):479–493. doi:10.1016/j.ecl.2019.05.001. - PMC - PubMed
    1. Coustan DR. Gestational diabetes mellitus. Clin Chem. 2013;59(9):1310–1321. doi:10.1373/clinchem.2013.203331. - PubMed
    1. Gao C, Sun X, Lu L, Liu F, Yuan J. Prevalence of gestational diabetes mellitus in mainland China:A systematic review and meta-analysis. J Diabetes Investig. 2019;10(1):154–162. doi:10.1111/jdi.12854. - PMC - PubMed
    1. Chu AHY, Godfrey KM. Gestational Diabetes Mellitus and Developmental Programming. Ann Nutr Metab. 2020;76(Suppl 3):4–15. doi:10.1159/000509902. - PMC - PubMed
    1. McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. Gestational diabetes mellitus. Nat Rev Dis Primers. 2019;5(1):47. doi:10.1038/s41572-019-0098-8. - PubMed

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