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. 2023 Jul-Sep;19(3):403-406.
doi: 10.4183/aeb.2023.403. Epub 2024 Feb 1.

ACTUALITIES IN THE MANAGEMENT OF SECONDARY HYPERPARATHYROIDISM DUE TO CHRONIC KIDNEY DISEASE IN CHILDREN

Affiliations

ACTUALITIES IN THE MANAGEMENT OF SECONDARY HYPERPARATHYROIDISM DUE TO CHRONIC KIDNEY DISEASE IN CHILDREN

M Gafencu et al. Acta Endocrinol (Buchar). 2023 Jul-Sep.

Abstract

Pediatric chronic kidney disease (CKD) has a substantial global impact because is associated with notable morbidity. Secondary hyperparathyroidism (SPHT) frequently emerges as a complication in the early stages of renal insufficiency, it is an adaptive response to uphold mineral balance. It is a component of the chronic kidney disease-mineral and bone disorder (CKD-MBD). The development of SHPT in CKD involves multiple factors and it is important to understand them in order to properly manage it, starting with early diagnosis and continuing with proper treatment. In children with CKD and SHPT, the difficulty in case management is due to non-adherence to proper diet which makes it difficult for the pediatric nephrologist to manage the case. In this review we want to focus on new data regarding this CKD complication.

Keywords: Children CKD; secondary hyper-parathyroidism.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

References

    1. Beng-Ongey H, Robinson JS, Moxey-Mims M. Chronic kidney disease emerging trends in children and what to do about it. J Natl Med Assoc. 2022;114(3S2):S50–S55. - PubMed
    1. Abukwaik WM, Baracco R, Jain A, Gregory M, Valentini RP, Kapur G. Clinical profile of children incidentally found to have advanced kidney failure. Pediatr Nephrol. 2022;37(5):1097–1103. - PubMed
    1. Bellorin-Font E, Vasquez-Rios G, Martin KJ. Controversies in the Management of Secondary Hyperparathyroidism in Chronic Kidney Disease. Curr Osteoporos Rep. 2019;17(5):333–342. - PubMed
    1. Silver J, Levi R. Regulation of PTH synthesis and secretion relevant to the management of secondary hyperparathyroidism in chronic kidney disease, Kidney International. 2005;67(Supp. 95):S8–S12. - PubMed
    1. Elshamaa MF, Eryan E, Hamed H, Khalifa I, Kamel S, Ibrahim MH, Kandil D, Farouk H, Raafat M, Abd-El Haleem DA, Mahmoud E, El-Saeed G, Abo HM, Abd EE, Sayed S. Vitamin D receptor gene polymorphisms in chronic kidney disease Egyptian children: effect on biochemical markers of bone mineral disorders. Pediatr Endocrinol Diabetes Metab. 2022;28(3):188–196. - PMC - PubMed

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