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. 2023 Sep;23(3):481-485.
doi: 10.4314/ahs.v23i3.55.

Treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bone grafting or bone migration and its effect on the levels of CRP, TNF-α and IL-6 in the serum

Xinqiang Wang  1 , Liangbang Wu  1 , Yuehong Zhang  1 , Zhenhai Hou  1 , Longbao Zheng  1 , Zenghui Gu  1
Affiliations

Treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bone grafting or bone migration and its effect on the levels of CRP, TNF-α and IL-6 in the serum

Xinqiang Wang et al. Afr Health Sci. 2023 Sep.

Abstract

Objective: To observe the effect of negative pressure closure drainage combined with open bone grafting or bone migration in the treatment of tibial traumatic osteomyelitis.

Methods: Eighty-six (86) cases of tibial traumatic osteomyelitis admitted to Hospital of the Chinese people's Liberation Army from September 2017 to September 2018 were randomly divided into control group and observation group, forty-three (43) cases each. Debridement, open bone grafting or bone migration was given to the control group.The observation group was treated with negative pressure closed drainage on the basis of the control group. In addition, the serum components such as CRP, TNF-α, IL-6 of the control group and observation group were detected respectively after surgery.

Results: Observation group granulation cover wound, fracture healing time was shorter than the control group, fracture healing rate was better than the control group, the difference has statistical significance (P<0.05). By comparing serum CRP, TNF-α, IL-6 levels before and after treatment in the two groups, it was found that the observation group was lower than the control group (P<0.05, respectively). Serum CRP, TNF-α, IL-6 levels were significantly (P<0.05).

Conclusion: The treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bone grafting or bone displacement has a good effect on fracture healing and is worth popularizing.

Keywords: Bone removal; CRP; IL-6; Negative pressure closure drainage; TNF-α; Tibia; Traumatic osteomyelitis.

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References

    1. Lowenberg DW, Buntic RF, Buncke GM, Parrett BM. Long-Term Results and Costs of Muscle Flap Coverage with Ilizarov Bone Transport in Lower Limb Salvage. Journal of Orthopaedic Trauma. 27(10):576–581. - PubMed
    1. Paley D, Maar D C. Ilizarov Bone Transport Treatment for Tibial Defects. Journal of Orthopaedic Trauma. 2000;14(2):76–85. - PubMed
    1. Girard PJ, Kuhn KM, Bailey JR, et al. Bone Transport Combined with Locking Bridge Plate Fixation for the Treatment of Tibial Segmental Defects: A Report of 2 Cases. Journal of Orthopaedic Trauma. 2012;27(9):220–226. - PubMed
    1. Struijs PAA, Poolman RW, Bhandari M. Infected Nonunion of the Long Bones. Journal of Orthopaedic Trauma. 2007;21(7):507–511. - PubMed
    1. Huljev D. Negative pressure therapy- supportive method in chronic wound treatment. Acta Medica Croatica Casopis Hravatske Akademije Medicinskih Znanosti. 2013;67(Suppl 1):89–94. - PubMed

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