Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep;23(3):245-253.
doi: 10.4314/ahs.v23i3.30.

Malignancy-related mir-210, mir-373 and let-7 levels are affected in iron deficiency anemia

Ruveyda Sak  1 , Demircan Ozbalci  2 , Emine Guchan Alanoglu  2 , Kuyas Hekimler Ozturk  3
Affiliations

Malignancy-related mir-210, mir-373 and let-7 levels are affected in iron deficiency anemia

Ruveyda Sak et al. Afr Health Sci. 2023 Sep.

Abstract

Background: Hypoxia is the hallmark of iron deficiency anemia (IDA) and in hypoxic environment, significant changes are observed in malignancy-related microRNAs (miRNA). Our aim is to examine whether there is any difference in the levels of miR-210, miR-373 and let-7, which are directly related to malignancies in patients with IDA.

Methods: Thirty-five female patients with IDA between the ages of 18-65 and 10 healthy controls were included in the study. Patients who received oral iron therapy, who had inflammatory disease, and who were pregnant were excluded from the study. Student t Test was used for comparing variables with normal distribution in two independent groups, and Mann-Whitney U Test was used for variables without normal distribution. Comparison of categorical data was made using the chi-square test.

Results: The mean hemoglobin and ferritin level were 10,78±0,93 and 6.28±5,76 respectively. Plasma miR-210 expression were found as -7.27±2.23 and -6.15±0,88 in IDA and control group respectively (p = 0.022). Plasma miRNA-373 were -7.36±2,58 and -6,96±1,93 and let-7 expression were 2.14±2,15 and 3,57±2,21 in IDA and control group. (p = 0.65 and p = 0.20, respectively).

Conclusions: Plasma miR-210 expression was significantly up-regulated and miR-373 and let-7 expression was down-regulated, though insignificantly, in IDA group.

Keywords: iron deficiency anemia; malignancy; miRNA.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest for the study.

Figures

Figure 1
Figure 1
Relative MiRNA levels between groups
See this image and copyright information in PMC

References

    1. Hung N, Shen CC, Hu YW, Hu LY, Yeh CM, Teng CJ, et al. Risk of cancer in patients with iron deficiency anemia: a nationwide population-based study. PLoS One. 2015 Mar 17;10(3):e0119647. Doi: 10.1371/journal.pone.0119647. Erratum in: PLoS One. 2015;10(4):e0125951. PMID: 25781632; PMCID: PMC4363660. - PMC - PubMed
    1. Joosten E. Iron deficiency anemia in older adults: A review. Geriatr Gerontol Int. 2018 Mar;18(3):373–379. Doi: 10.1111/ggi.13194. Epub 2017 Nov 2. PMID: 29094497. - PubMed
    1. Tymoszuk P, Nairz M, Brigo N, Petzer V, Heeke S, Kircher B, et al. Iron Supplementation Interferes with Immune Therapy of Murine Mammary Carcinoma by Inhibiting Anti-Tumor T Cell Function. Front Oncol. 2020 Dec 4;10:584477. Doi: 10.3389/fonc.2020.584477. PMID: 33344239; PMCID: PMC7746876. - PMC - PubMed
    1. Harrison IP, Selemidis S. Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets. Clin Exp Pharmacol Physiol. 2014 Aug;41(8):533–542. Doi: 10.1111/1440-1681.12238. PMID: 24738947. - PubMed
    1. Prá D, Franke SI, Henriques JA, Fenech M. Iron and genome stability: an update. Mutat Res. 2012 May 1;733(1-2):92–99. Doi: 10.1016/j.mrfmmm.2012.02.001. Epub 2012 Feb 13. PMID: 22349350. - PubMed

LinkOut - more resources