Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jan 30:18:1328790.
doi: 10.3389/fnbeh.2024.1328790. eCollection 2024.

Postoperative cognitive dysfunction-current research progress

Qi Zhao #  1 , Hui Wan #  1 , Hui Pan  1 , Yiquan Xu  1
Affiliations
Review

Postoperative cognitive dysfunction-current research progress

Qi Zhao et al. Front Behav Neurosci. .

Abstract

Postoperative cognitive dysfunction (POCD) commonly occurs after surgery, particularly in elderly individuals. It is characterized by a notable decline in cognitive performance, encompassing memory, attention, coordination, orientation, verbal fluency, and executive function. This reduction in cognitive abilities contributes to extended hospital stays and heightened mortality. The prevalence of POCD can reach 40% within 1 week following cardiovascular surgery and remains as high as 17% 3 months post-surgery. Furthermore, POCD exacerbates the long-term risk of Alzheimer's disease (AD). As a result, numerous studies have been conducted to investigate the molecular mechanisms underlying POCD and potential preventive strategies. This article provides a review of the research progress on POCD.

Keywords: POCD; pathogenesis; prevention; review; risk factors.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Abramoff B., Caldera F. E. (2020). Osteoarthritis: pathology, diagnosis, and treatment options. Med. Clin. North Am. 104, 293–311. doi: 10.1016/j.mcna.2019.10.007 - DOI - PubMed
    1. Alam A., Hana Z., Jin Z., Suen K. C., Ma D. (2018). Surgery, neuroinflammation and cognitive impairment. EBioMedicine 37, 547–556. doi: 10.1016/j.ebiom.2018.10.021, PMID: - DOI - PMC - PubMed
    1. Amidfar M., de Oliveira J., Kucharska E., Budni J., Kim Y. K. (2020). The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease. Life Sci. 257:118020. doi: 10.1016/j.lfs.2020.118020, PMID: - DOI - PubMed
    1. Ancelin M. L., de Roquefeuil G., Scali J., Bonnel F., Adam J. F., Cheminal J. C., et al. (2010). Long-term post-operative cognitive decline in the elderly: the effects of anesthesia type, apolipoprotein E genotype, and clinical antecedents. J. Alzheimers Dis. 22 Suppl 3, 105–113. doi: 10.3233/jad-2010-100807, PMID: - DOI - PMC - PubMed
    1. Ando S., Kobayashi S., Waki H., Kon K., Fukui F., Tadenuma T., et al. (2002). Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine. J. Neurosci. Res. 70, 519–527. doi: 10.1002/jnr.10443, PMID: - DOI - PubMed