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Review
. 2024 Mar;14(3):68.
doi: 10.1007/s13205-024-03925-8. Epub 2024 Feb 13.

Natural flavonoids as potential therapeutics in the management of Alzheimer's disease: a review

Phuong-Trang Nguyen-Thi #  1 , Tuong Kha Vo  2 , Thi Hong Trang Pham  3   4 , Thuy Trang Nguyen  5 , Giau Van Vo #  6   7   8
Affiliations
Review

Natural flavonoids as potential therapeutics in the management of Alzheimer's disease: a review

Phuong-Trang Nguyen-Thi et al. 3 Biotech. 2024 Mar.

Abstract

Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder which is associated with the accumulation of proteotoxic Aβ peptides, and pathologically characterized by the deposition of Aβ-enriched plaques and neurofibrillary tangles. Given the social and economic burden caused by the rising frequency of AD, there is an urgent need for the development of appropriate therapeutics. Natural compounds are gaining popularity as alternatives to synthetic drugs due to their neuroprotective properties and higher biocompatibility. While natural compound's therapeutic effects for AD have been recently investigated in numerous in vitro and in vivo studies, only few have developed to clinical trials. The present review aims to provide a brief overview of the therapeutic effects, new insights, and upcoming perspectives of the preclinical and clinical trials of flavonoids for the treatment of Alzheimer's disease.

Keywords: Alzheimer's disease; Clinical trials; Flavonoids; Natural products; Neuroprotection.

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Conflict of interest statement

Conflict of interestOn behalf of all authors, the corresponding author states that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
An overview of Alzheimer’s disease pathophysiology
Fig. 2
Fig. 2
Neuroprotective effect of flavonoids in neuroinflammation and neurodegeneration through different mechanisms of action
Fig. 3
Fig. 3
Overview of the multiple mechanisms of action of natural products as neuroprotective agents against Alzheimer’s disease (AD), (da Rosa, de Amorim et al. 2022)
Fig. 4
Fig. 4
Therapeutic potential of flavonoids through regulating various pathways in Alzheimer’s disease (Minocha et al. 2022)
See this image and copyright information in PMC

References

    1. Agullo G, Gamet-Payrastre L, Manenti S, Viala C, Rémésy C, Chap H, Payrastre B. Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol. 1997;53(11):1649–1657. doi: 10.1016/S0006-2952(97)82453-7. - DOI - PubMed
    1. Ahmed RM, Ke YD, Vucic S, Ittner LM, Seeley W, Hodges JR, Piguet O, Halliday G, Kiernan MC. Physiological changes in neurodegeneration—mechanistic insights and clinical utility. Nat Rev Neurol. 2018;14(5):259–271. doi: 10.1038/nrneurol.2018.23. - DOI - PubMed
    1. Albert-Gascó H, Ros-Bernal F, Castillo-Gómez E, Olucha-Bordonau FE. MAP/ERK signaling in developing cognitive and emotional function and its effect on pathological and neurodegenerative processes. Int J Mol Sci. 2020;21(12):4471. doi: 10.3390/ijms21124471. - DOI - PMC - PubMed
    1. Alharbi MH, Lamport DJ, Dodd GF, Saunders C, Harkness L, Butler LT, Spencer JP. Flavonoid-rich orange juice is associated with acute improvements in cognitive function in healthy middle-aged males. Eur J Nutr. 2016;55(6):2021–2029. doi: 10.1007/s00394-015-1016-9. - DOI - PMC - PubMed
    1. Ali T, Kim T, Rehman SU, Khan MS, Amin FU, Khan M, Ikram M, Kim MO. Natural dietary supplementation of anthocyanins via PI3K/Akt/Nrf2/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse model of Alzheimer's disease. Mol Neurobiol. 2018;55(7):6076–6093. doi: 10.1007/s12035-017-0798-6. - DOI - PubMed

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