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Review
. 2024 Aug;397(8):5335-5362.
doi: 10.1007/s00210-024-02972-5. Epub 2024 Feb 15.

Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite

Atousa Moghadam Fard  1 , Pardis Goodarzi  2 , Mehran Mottahedi  3 , Setareh Garousi  3 , Hamed Zadabhari  4 , Mohammad Kalantari Shahijan  5 , Saeedeh Esmaeili  6 , Mohsen Nabi-Afjadi  7 , Bahman Yousefi  8   9
Affiliations
Review

Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite

Atousa Moghadam Fard et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Aug.

Abstract

Most animals have large amounts of the special substance melatonin, which is controlled by the light/dark cycle in the suprachiasmatic nucleus. According to what is now understood, the gastrointestinal tract (GIT) and other areas of the body are sites of melatonin production. According to recent studies, the GIT and adjacent organs depend critically on a massive amount of melatonin. Not unexpectedly, melatonin's many biological properties, such as its antioxidant, anti-inflammatory, pro-apoptotic, anti-proliferative, anti-metastasis, and antiangiogenic properties, have drawn the attention of researchers more and more. Because melatonin is an antioxidant, it produces a lot of secretions in the GIT's mucus and saliva, which shields cells from damage and promotes the development of certain GIT-related disorders. Melatonin's ability to alter cellular behavior in the GIT and other associated organs, such as the liver and pancreas, is another way that it functions. This behavior alters the secretory and metabolic activities of these cells. In this review, we attempted to shed fresh light on the many roles that melatonin plays in the various regions of the gastrointestinal tract by focusing on its activities for the first time.

Keywords: Antioxidant; Gastrointestinal tract; IBD; Melatonin.

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