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Case Reports
. 2023 Dec 29;29(3):102180.
doi: 10.1016/j.jaccas.2023.102180. eCollection 2024 Feb 7.

Mechanical Tricuspid Valve Thrombosis Successfully Treated With Tissue Plasminogen Activator

Rebecca Haraf  1   2 , Tamara Atkinson  1 , Dai-Trang Elizabeth Le  1 , Bhaskar Arora  1
Affiliations
Case Reports

Mechanical Tricuspid Valve Thrombosis Successfully Treated With Tissue Plasminogen Activator

Rebecca Haraf et al. JACC Case Rep. .

Abstract

Prosthetic mechanical valve thrombosis has traditionally been managed with urgent surgical intervention. However, the risk of redo sternotomy can be prohibitively high in some patients. Thrombolytic therapy as a noninvasive treatment of mechanical valve thrombosis is a well-recognized alternative, but optimal dosing and patient selection remain incompletely characterized for right-side mechanical valves.

Keywords: 3D echocardiography; fluoroscopy; mechanical tricuspid valve; thrombolytics; thrombosis; tissue plasminogen activator.

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Conflict of interest statement

The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Figures

None
Graphical abstract
Figure 1
Figure 1
Elevated Peak and Mean Prosthetic Tricuspid Valve Gradients Transthoracic echocardiogram with continuous-wave Doppler across the mechanical tricuspid valve (TV) in the apical 4-chamber view, demonstrating elevated velocity and mean gradient. Pressure half-time was 230 ms, consistent with valvular obstruction.
Figure 2
Figure 2
Normalization of Peak and Mean Prosthetic Tricuspid Valve Gradients Transthoracic echocardiogram with continuous-wave Doppler across the mechanical tricuspid valve (TV) in the right ventricular inflow tract view, demonstrating normal velocity and improvement in peak and mean gradients.
See this image and copyright information in PMC

References

    1. Lancellotti P., Pibarot P., Chambers J., et al. Recommendations for the imaging assessment of prosthetic heart valves: a report from the European Association of Cardiovascular Imaging endorsed by the Chinese Society of Echocardiography, the Inter-American Society of Echocardiography, and the Brazilian Department of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2016;17(6):589–590. - PubMed
    1. Dangas G.D., Weitz J.I., Giustino G., et al. Prosthetic heart valve thrombosis. J Am Coll Cardiol. 2016;68:2670–2689. - PubMed
    1. Zhu X., Luo Y., Zhang E., et al. Ten-year experience of tricuspid valve replacement with the St. Jude medical valve. Sci Rep. 2018;8(1) - PMC - PubMed
    1. Muratori M., Fusini L., Ghulam Ali S., et al. Detection of mechanical prosthetic valve dysfunction. Am J Cardiol. 2021;150:101–109. - PubMed
    1. Otto C.M., Nishimura R.A., Bonow R.O., et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2021;77(4):e25–e197. - PubMed

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