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. 2024 Feb 1:11:1334036.
doi: 10.3389/fvets.2024.1334036. eCollection 2024.

Large-scale serological survey on Mycobacterium avium subsp. paratuberculosis infection in sheep and goat herds in Sicily, Southern Italy

Vincenzo Di Marco Lo Presti  1 , Dorotea Ippolito  1   2 , Sergio Migliore  1 , Marco Tolone  3 , Sebastian Alessandro Mignacca  4 , Anna Maria Fausta Marino  1 , Benedetta Amato  5 , Rosita Calogero  1 , Maria Vitale  1 , Domenico Vicari  1 , Flavia Pruiti Ciarello  1 , Michele Fiasconaro  1
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Large-scale serological survey on Mycobacterium avium subsp. paratuberculosis infection in sheep and goat herds in Sicily, Southern Italy

Vincenzo Di Marco Lo Presti et al. Front Vet Sci. .

Abstract

Introduction: Paratuberculosis (PTB) is a worldwide chronic, contagious enteric disease caused by Mycobacterium avium subsp. paratuberculosis (MAP) mainly affecting ruminant species. PTB is a WOAH-listed disease with direct and indirect economic losses in the livestock sector, negative impact on animal welfare and significant public health concerns. In spite of this, MAP prevalence in small ruminants is still unknown and the prevalence appears to be underestimated in many countries. The aim of this study is providing a first large-scale serological survey on MAP infection in small ruminants in Sicily, a region of Southern Italy with the 11.3 and 8.9% Italian national heritage of sheep and goats, respectively.

Methods: For this purpose, we analyzed a total of 48,643 animals reared in 439 flocks throughout Sicily. MAP seroprevalence was estimated both at herd-level and animal-level within breeds reared in all the nine sampled provinces.

Results: Our results revealed a high overall apparent prevalence at herd-level of 71.8% in sheep and 60.8% in goat farms with an animal-level prevalence of 4.5 and 5.1% in sheep and goats, respectively. Significant statistical differences were found between the provinces and within the breeds both in sheep and goats.

Discussion: Our study provides the first large-scale serological survey on PTB infection in small ruminants in Sicily and showed a high prevalence of disease depending to the species, breed and province. This study represents the first step to better understand the MAP epidemiology in a typical Mediterranean breeding context, suggesting the need of in-depth study on the herds risk factors, including the eventual presence of candidate genes for resistance/susceptibility to PTB in native breeds.

Keywords: Italy; Mycobacterium avium subsp. paratuberculosis; Sicily; goat; paratuberculosis; seroprevalence; sheep.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Map of the study area with sampled sheep and goat farms for province.
See this image and copyright information in PMC

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References

    1. Roller M, Hansen S, Knauf-Witzens T, Oelemann WMR, Czerny C-P, Abd El Wahed A, et al. . Mycobacterium avium subspecies paratuberculosis infection in zoo animals: a review of susceptibility and disease process. Front Vet Sci. (2020) 7:572724. doi: 10.3389/fvets.2020.572724, PMID: - DOI - PMC - PubMed
    1. Garvey M. Mycobacterium avium subspecies paratuberculosis: a possible causative agent in human morbidity and risk to public health safety. Open Vet J. (2018) 8:172–81. doi: 10.4314/ovj.v8i2.10, PMID: - DOI - PMC - PubMed
    1. Feller M, Huwiler K, Stephan R, Altpeter E, Shang A, Furrer H, et al. . Mycobacterium avium subspecies paratuberculosis and Crohn’s disease: a systematic review and meta-analysis. Lancet Infect Dis. (2007) 7:607–13. doi: 10.1016/S1473-3099(07)70211-6, PMID: - DOI - PubMed
    1. Sechi LA, Dow CT. Mycobacterium avium ss. Paratuberculosis zoonosis – the hundred year war– beyond Crohn’s disease. Front Immunol. (2015) 6:96. doi: 10.3389/fimmu.2015.00096, PMID: - DOI - PMC - PubMed
    1. Cossu A, Rosu V, Paccagnini D, Cossu D, Pacifico A, Sechi LA. MAP 3738c and Mpt D are specific tags of Mycobacterium avium subsp. paratuberculosis infection in type I diabetes mellitus. Clin Immunol. (2011) 141:49–57. doi: 10.1016/j.clim.2011.05.002, PMID: - DOI - PubMed

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