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. 2024 Feb 1:11:1321981.
doi: 10.3389/fsurg.2024.1321981. eCollection 2024.

Prognostic factors in gastric cancer patients: a 10-year mono-institutional experience

N De Ruvo  1 , S Fenocchi  1 , L Veronesi  1 , G Missori  1 , A A Ricciardolo  1 , E G Rossi  1 , L Sorrentino  1 , N Cautero  1 , F Serra  1 , R Gelmini  1
Affiliations

Prognostic factors in gastric cancer patients: a 10-year mono-institutional experience

N De Ruvo et al. Front Surg. .

Abstract

Introduction: Gastric cancer (GC) is one of the main causes of death from cancer globally. Long-term survival, especially in Western countries, remains dismal, with no significant improvements in recent years. Therefore, precise identification of clinical and pathological risk factors is crucial for prognosis, as it allows a better selection of patients suitable for oncologically radical treatments and contributes to longer survivals.

Methods: We devised a retrospective observational longitudinal study over 10 years of experience with GC patients operated with curative intent.

Results: Several factors were thoroughly investigated in a multivariate analysis to look for significance as independent risk factors for disease-free survival. Our results showed that only BMI, pTNM, and lymph node ratio expressed hazard ratios with implications for survival in our series of patients.

Discussion: Although limited by the retrospective nature of the study, this is one of the few cancer reports from Northern Italy showing results over 10 years, which may in our view, have an impact on decision-making processes for multidisciplinary teams dedicated to the care of gastric cancer patients.

Keywords: gastrectomy; gastric cancer; prognostic factors; risk factor; survival after surgery.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Inclusion and exclusion criteria and final population.
Figure 2
Figure 2
BMI (curve a) and Lauren histotype (curve b).
Figure 3
Figure 3
LN ratio and DFS (curve a) and pTNM stages and DFS (curve b).
Figure 4
Figure 4
Grading and DFS (curve a), vascular budding and DFS (curve b), perineural infiltration and DFS (curve c), and R positivity and DFS (curve d).
Figure 5
Figure 5
NLR and DFS (curve a), PLR and DFS (curve b), and LMR and DFS (curve c).
Figure 6
Figure 6
Complications and DFS (curve a) and post-operative chemotherapy and DFS (curve b).
See this image and copyright information in PMC

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