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. 2024 Aug;46(8):2010-2019.
doi: 10.1002/hed.27694. Epub 2024 Feb 16.

Next-generation sequencing reveals remarkable genetic stability in primary and corresponding recurrent intestinal-type sinonasal adenocarcinoma

Cristina Riobello  1 , Paula Sánchez-Fernández  2 , María Camila Cubides Córdoba  2 , Maripaz González-Gutiérrez  3 , Blanca Vivanco  3 , Virginia N Cabal  1 , Laura Suárez Fernández  1 , Rocío García-Marín  1 , Helena Codina-Martínez  1 , Sara Lucila Lorenzo-Guerra  1 , Fernando López  2 , Mario A Hermsen  1 , José Luis Llorente  2
Affiliations

Next-generation sequencing reveals remarkable genetic stability in primary and corresponding recurrent intestinal-type sinonasal adenocarcinoma

Cristina Riobello et al. Head Neck. 2024 Aug.

Abstract

Background: Recurrent intestinal-type sinonasal adenocarcinoma (ITAC) can occur several years after primary treatment and with different histology. We aimed to clarify if such recurrences could be second primary tumors and to identify actionable mutations as targets for personalized treatment of recurrent ITAC.

Methods: Twelve pairs of primary and recurrent ITAC were histologically examined and analyzed by next-generation sequencing.

Results: Histological differences between primary and recurrent tumor pairs were observed in five cases. Frequent mutations included TP53, APC, TSC2, ATM, EPHA2, BRCA2, LRP1B, KRAS, and KMT2B. There was 86% concordance of somatic mutations between the tumor pairs, while four cases carried additional mutations in the recurrence.

Conclusions: We found all cases to be clonal recurrences and not second primary tumors. Moreover, tumor pairs showed a remarkable genomic stability, suggesting that personalized treatment of a recurrence may be based on actionable molecular genetic targets observed in the primary tumor.

Keywords: actionable mutations; histopathology; intestinal‐type adenocarcinoma; relapse; sinonasal cancer.

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References

REFERENCES

    1. Llorente JL, López F, Suárez C, Hermsen M. Sinonasal carcinoma: clinical, pathological and genetic advances for new therapeutic opportunities. Nat Rev Clin Oncol. 2014;11(8):460‐472.
    1. Blot WJ, Chow WH, McLaughlin JK. Wood dust and nasal cancer risk. J Occup Environ Med. 1997;39(2):148‐156.
    1. El‐Naggar AK, Chan J, Takata T, et al. WHO Classification of Tumors Pathology and Genetics of Head and Neck Tumors. 4th ed. IARC Press; 2017.
    1. Leivo I. Sinonasal adenocarcinoma: update on classification, immunophenotype and molecular features. Head Neck Pathol. 2017;11:295‐300.
    1. Nicolai P, Schreiber A, Bolzoni Villaret A, et al. Intestinal type adenocarcinoma of the ethmoid: outcomes of a treatment regimen based on endoscopic surgery with or without radiotherapy. Head Neck. 2016;38(Suppl 1):996‐1003.

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