Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb 16;166(1):86.
doi: 10.1007/s00701-024-05938-x.

Improvement of metabolic syndrome and its components in patients who underwent transsphenoidal resection for pituitary adenoma

A P Cortés-Contreras  1   2   3   4 , A Salazar-Pigeon  2   3 , J A González-Almazán  1   2 , R Flores-Rabasa  1   2   5 , J L Navarro-Olvera  1 , L A Méndez-García  2 , J D Carrillo-Ruiz  6   7   8
Affiliations

Improvement of metabolic syndrome and its components in patients who underwent transsphenoidal resection for pituitary adenoma

A P Cortés-Contreras et al. Acta Neurochir (Wien). .

Abstract

Background: Pituitary adenomas (PA) are neoplasms of pituitary adenohypophyseal cell lineage, which are the third most common cause of brain tumors among adults. Due to hormone secretion, PAs are closely related to metabolic syndrome (MetS). However, the relationship between these two entities has been scarcely studied to date.

Purpose: This paper aims to evaluate changes in the metabolic status of patients with PA before and after surgical treatment and to look for differences in metabolic outcomes among patients according to the adenoma type and the surgery success rate.

Methods: We assessed patients with PA who went through transsphenoidal surgery for its treatment, documenting metabolic parameters before and after surgery, analyzed whole sample changes, and then stratified them according to adenoma type (nonfunctioning, somatotroph, lactotroph, and corticotroph), and surgery success (total resection, near-total resection, partial resection, subtotal resection).

Results: A total of 214 patients were enrolled for this study. The prevalence of MetS with AACE criteria went from 51.52% before surgery to 28.99% after surgery (P < 0.001). Hyperglycemia (HG) was the most beneficial component; it went from 56% pre-surgery to 40.51% post-surgery (P = 0.03). The total resection group had the best improvement, with a significant decrease of prevalence in MetS from 83 to 16% (P < 0.001), and every component, except hypoalphalipoproteinemia (HA): obesity went from 96 to 67% (P < 0.001), arterial hypertension (AH) 59 to 24% (P < 0.001), HG 74 to 23% (P < 0.001), and hypertriglyceridemia (HTG) from 81 to 54% (P < 0.001). According to MetS prevalence, there was no difference in the improvement according to PA type.

Conclusion: Surgical treatment in patients with PA is associated with MetS improvement.

Keywords: Metabolic components; Metabolic syndrome; Pituitary adenoma; Transsphenoidal surgery.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Altuntaś SÇ, Evran M, Sert M, Tetiker T (2019) Markers of metabolic syndrome in patients with pituitary adenoma: a case series of 303 patients. Horm Metab Res. https://doi.org/10.1055/a-1020-3992 - DOI - PubMed
    1. American Diabetes Association (2020) Classification and diagnosis of diabetes: standards of medical care in diabetes. Diabetes Care 43(Supplement_1):S14–S31 - DOI
    1. Ausiello JC, Bruce JN, Freda PU (2008) Postoperative assessment of the patient after transsphenoidal pituitary surgery. Pituitary. https://doi.org/10.1007/s11102-008-0086-6 - DOI - PubMed
    1. Baba N, Kameda H, Nakamura A, Cho KY, Nomoto H, Mitsuhashi T, Atsumi T (2021) Silent pituitary adenoma and metabolic disorders: obesity, abnormal glucose tolerance, hypertension and dyslipidemia. Endocr J. https://doi.org/10.1507/endocrj.EJ20-0185 - DOI - PubMed
    1. Ben-Jonathan N, Hugo ER, Brandebourg TD, LaPensee CR (2006) Focus on prolactin as a metabolic hormone. TEM. https://doi.org/10.1016/j.tem.2006.02.005 - DOI - PubMed

LinkOut - more resources