Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Sep;53(9):1909-1924.
doi: 10.1007/s00256-024-04615-5. Epub 2024 Feb 16.

Pathology of intra-articular tumours and tumour-like lesions: pearls, pitfalls and rarities from a general surgical pathology practice

Alison L Cheah  1 , Wendy Brown  2 , S Fiona Bonar  3
Affiliations
Review

Pathology of intra-articular tumours and tumour-like lesions: pearls, pitfalls and rarities from a general surgical pathology practice

Alison L Cheah et al. Skeletal Radiol. 2024 Sep.

Abstract

Intra-articular tumours are uncommonly encountered in routine practice and may present diagnostic challenges to pathologists. Challenges unique to this site include distinction from more common reactive synovial conditions, which are far more common; histologic variability; superimposed reactive changes; and often, lack of provided clinicoradiological context. This article reviews the pathology of the synovial tumours and tumour-like lesions, including diagnostic pearls, pitfalls and rare entities.

Keywords: Hoffa’s disease; Intra-articular nodular fasciitis; Intra-articular peripheral nerve sheath tumour; Lipoma arborescens; Synovial chondromatosis; Synovial haemangioma; Tenosynovial giant cell tumour.

PubMed Disclaimer

References

    1. WHO Classification of Tumours Editorial Board. Soft tissue and bone tumours. WHO classification of tumours. Lyon: IARC Press; 2020.
    1. Goldblum JR, Folpe AL, Weiss SW. Benign tumors and tumor-like lesions of synovial tissue. In: Goldblum JR, Folpe AL, Weiss SW, editors. Enzinger and Weiss’s soft tissue tumors. Philadelphia: Elsevier; 2014. p. 766–79.
    1. Murphey MD, et al. Pigmented villonodular synovitis: radiologic-pathologic correlation. Radiographics. 2008;28(5):1493–518. - PubMed - DOI
    1. Somerhausen NS, Fletcher CD. Diffuse-type giant cell tumor: clinicopathologic and immunohistochemical analysis of 50 cases with extraarticular disease. Am J Surg Pathol. 2000;24(4):479–92. - PubMed - DOI
    1. Palmerini E, et al. Tenosynovial giant cell tumour/pigmented villonodular synovitis: outcome of 294 patients before the era of kinase inhibitors. Eur J Cancer. 2015;51(2):210–7. - PubMed - DOI

MeSH terms

LinkOut - more resources