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Review
. 2024 Feb 17;23(1):49.
doi: 10.1186/s12944-024-02016-0.

TRP channels associated with macrophages as targets for the treatment of obese asthma

Wenzhao Zhu #  1 , Dinxi Bai #  1 , Wenting Ji  2 , Jing Gao  3
Affiliations
Review

TRP channels associated with macrophages as targets for the treatment of obese asthma

Wenzhao Zhu et al. Lipids Health Dis. .

Abstract

Globally, obesity and asthma pose significant health challenges, with obesity being a key factor influencing asthma. Despite this, effective treatments for obese asthma, a distinct phenotype, remain elusive. Since the discovery of transient receptor potential (TRP) channels in 1969, their value as therapeutic targets for various diseases has been acknowledged. TRP channels, present in adipose tissue cells, influence fat cell heat production and the secretion of adipokines and cytokines, which are closely associated with asthma and obesity. This paper aims to investigate the mechanisms by which obesity exacerbates asthma-related inflammation and suggests that targeting TRP channels in adipose tissue could potentially suppress obese asthma and offer novel insights into its treatment.

Keywords: Asthma; Inflammation; Obese asthma; Obesity; TRP channels.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The inflammatory mechanisms of asthma related to TRP channels. This figure mainly describes the influence of fat cells and their surrounding immune cells on the inflammatory state of asthma when the TRP channel is activated, and this inflammatory state builds a bridge between obesity and asthma
Fig. 2
Fig. 2
TRP channels on adipose tissue cells participate in the mechanism of obese asthma
Fig. 3
Fig. 3
A TRP channels on M1 macrophages participate in the mechanism of obese asthma; B TRP channels on M2 macrophages participate in the mechanism of obese asthma
See this image and copyright information in PMC

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