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Review
. 2024 Feb;31(2):216-218.
doi: 10.1038/s41594-024-01221-w. Epub 2024 Feb 16.

Breaking the K48-chain: linking ubiquitin beyond protein degradation

Sanim Rahman  1 , Cynthia Wolberger  2
Affiliations
Review

Breaking the K48-chain: linking ubiquitin beyond protein degradation

Sanim Rahman et al. Nat Struct Mol Biol. 2024 Feb.

Abstract

The discovery of ubiquitin conjugation to lysines and the role of K48-linked polyubiquitin in targeting substrates for proteasomal degradation was followed by revelation of non-degradative roles of ubiquitination and, more recently, of non-canonical covalent ubiquitin linkages. Here we summarize findings of the ever-expanding array of ubiquitin signals and their biological roles.

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Conflict of interest statement

Competing interests

The authors declare no competing interests.

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