Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun;193(3):1283-1287.
doi: 10.1007/s11845-024-03638-0. Epub 2024 Feb 17.

Investigation of MHR-nephropathy relationship and the effect of SGLT2is on MHR in patients with type 2 diabetes

Bedriye Gizem Tekin  1 , Erengül Pektaş  2
Affiliations

Investigation of MHR-nephropathy relationship and the effect of SGLT2is on MHR in patients with type 2 diabetes

Bedriye Gizem Tekin et al. Ir J Med Sci. 2024 Jun.

Abstract

Objective: The aim of this study was to evaluate the relationship between monocyte/high-density lipoprotein (HDL) ratio (MHR), an inflammatory marker, and diabetic nephropathy (DN), a microvascular complication of diabetes in diabetic patients and to investigate the effect of sodium-glucose co-transporter 2 inhibitors (SGLT2i) on MHR.

Material and methods: The study included 119 diabetic patients. Hemogram, glucose, HbA1c, urea, creatinine, albumin, HDL cholesterol, LDL cholesterol, triglycerides, total cholesterol, MHR, NLR (neutrophil-lymphocyte ratio), and CRP parameters were evaluated in blood parameters taken after 8-10 h of fasting before and 6 months after SGLT2 inhibitor use, and albumin, creatinine, and albumin/creatinine parameters were evaluated in urine samples. Parameters were compared according to nephropathy status and SGLT2i type used.

Results: The MHR in diabetic nephropathy (DN (+)) patients was significantly higher than in DN (-) patients (p = 0.005). There was no significant difference in NLR value in both groups. The MHR value decreased significantly after the use of SGLT2i in all patients participating in the study (p = 0.01). NLR value decreased in DN (-) patients after SGLT2i use. No difference was observed in DN (+) patients.

Conclusion: In this study, results supporting the relationship between DN and MHR and the effect of SGLT2i drugs on MHR were found. The use of MHR value as a marker in clinical course monitoring and shaping the treatment according to these markers may be useful in terms of prediction and treatment of complications.

Keywords: Diabetes mellitus; MHR; NLR; Nephropathy; SGLT2.

PubMed Disclaimer

References

    1. Turkısh Diabetes Mellitus Study and Education Group (2022) TEMD diabetes mellitus and complications diagnosis, treatment and follow-up guideline. [cited 2022 Oct 9]. p 15–186. Available from: https://file.temd.org.tr/Uploads/publications/guides/documents/diabetes-...
    1. Bennett K, Aditya BS (2015) An overview of diabetic nephropathy: epidemiology, pathophysiology and treatment. J Diabetes Nurs 19(2):61–7
    1. Warren AM, Knudsen ST, Cooper ME (2019) Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies. Expert Opin Ther Targets. 23(7):579–591. https://doi.org/10.1080/14728222.2019.1624721 - DOI - PubMed
    1. (2023) Kidney Int 103(2):282-296. https://doi.org/10.1016/j.kint.2022.10.030 . Epub 2022 Dec 5.PMID:36470394Review
    1. (2019) Am J Cardiol 124(Suppl 1): S28–S35. https://doi.org/10.1016/j.amjcard.2019.10.027

LinkOut - more resources