Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Feb 17;51(1):308.
doi: 10.1007/s11033-024-09288-w.

Interaction between lncRNAs and RNA-binding proteins (RBPs) influences DNA damage response in cancer chemoresistance

Forough Alemi  1 , Yadollah Poornajaf  2 , Foroogh Hosseini  3 , Vahid Vahedian  4 , Mahdi Gharekhani  5 , Hamed Shoorei  6   7   8 , Mohammad Taheri  9   10
Affiliations
Review

Interaction between lncRNAs and RNA-binding proteins (RBPs) influences DNA damage response in cancer chemoresistance

Forough Alemi et al. Mol Biol Rep. .

Abstract

The DNA damage response (DDR) is a crucial cellular signaling pathway activated in response to DNA damage, including damage caused by chemotherapy. Chemoresistance, which refers to the resistance of cancer cells to the effects of chemotherapy, poses a significant challenge in cancer treatment. Understanding the relationship between DDR and chemoresistance is vital for devising strategies to overcome this resistance and improve treatment outcomes. Long non-coding RNAs (lncRNAs) are a class of RNA molecules that do not code for proteins but play important roles in various biological processes, including cancer development and chemoresistance. RNA-binding proteins (RBPs) are a group of proteins that bind to RNA molecules and regulate their functions. The interaction between lncRNAs and RBPs has been found to regulate gene expression at the post-transcriptional level, thereby influencing various cellular processes, including DDR signaling pathways. Multiple studies have demonstrated that lncRNAs can interact with RBPs to modulate the expression of genes involved in cancer chemoresistance by impacting DDR signaling pathways. Conversely, RBPs can regulate the expression and function of lncRNAs involved in DDR. Exploring these interactions can provide valuable insights for the development of innovative therapeutic approaches to overcome chemoresistance in cancer patients. This review article aims to summarize recent research on the interaction between lncRNAs and RBPs during cancer chemotherapy, with a specific focus on DDR pathways.

Keywords: Cancer; Chemoresistance; DNA damage response (DDR); Long non-coding RNAs (lncRNAs); RNA-binding proteins (RBPs).

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Su M, Wang H, Wang W, Wang Y, Ouyang L, Pan C et al (2018) LncRNAs in DNA damage response and repair in cancer cells. Acta Biochim Biophys Sin 50(5):433–439 - PubMed
    1. Adriaens C, Standaert L, Barra J, Latil M, Verfaillie A, Kalev P et al (2016) p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nat Med 22(8):861–868 - PubMed
    1. Özeş AR, Miller DF, Özeş ON, Fang F, Liu Y, Matei D et al (2016) NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer. Oncogene 35(41):5350–5361 - PMC
    1. Xiao H, Liu Y, Liang P, Wang B, Tan H, Zhang Y et al (2018) TP53TG1 enhances cisplatin sensitivity of non-small cell lung cancer cells through regulating miR-18a/PTEN axis. Cell Biosci 8(1):1–13
    1. Astanehe A, Finkbeiner M, Hojabrpour P, To K, Fotovati A, Shadeo A et al (2009) The transcriptional induction of PIK3CA in tumor cells is dependent on the oncoprotein Y-box binding protein-1. Oncogene 28(25):2406–2418 - PubMed

LinkOut - more resources