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Review
. 2024 Feb 17;409(1):65.
doi: 10.1007/s00423-024-03259-2.

Modern insights into the pathophysiology and treatment of pseudoachalasia

Leonardo Yuri Kasputis Zanini  1 , Fernando A M Herbella  2 , Vic Velanovich  3 , Marco G Patti  4
Affiliations
Review

Modern insights into the pathophysiology and treatment of pseudoachalasia

Leonardo Yuri Kasputis Zanini et al. Langenbecks Arch Surg. .

Abstract

Background: Secondary achalasia or pseudoachalasia is a clinical presentation undistinguishable from achalasia in terms of symptoms, manometric, and radiographic findings, but associated with different and identifiable underlying causes.

Methods: A literature review was conducted on the PubMed database restricting results to the English language. Key terms used were "achalasia-like" with 63 results, "secondary achalasia" with 69 results, and "pseudoachalasia" with 141 results. References of the retrieved papers were also manually reviewed.

Results: Etiology, diagnosis, and treatment were reviewed.

Conclusions: Pseudoachalasia is a rare disease. Most available evidence regarding this condition is based on case reports or small retrospective series. There are different causes but all culminating in outflow obstruction. Clinical presentation and image and functional tests overlap with primary achalasia or are inaccurate, thus the identification of secondary achalasia can be delayed. Inadequate diagnosis leads to futile therapies and could worsen prognosis, especially in neoplastic disease. Routine screening is not justifiable; good clinical judgment still remains the best tool. Therapy should be aimed at etiology. Even though Heller's myotomy brings the best results in non-malignant cases, good clinical judgment still remains the best tool as well.

Keywords: Bariatric surgery; Esophageal achalasia; Esophageal motility disorders; Esophagus; Pseudoachalasia; Stomach neoplasms.

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