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. 2024 Mar;40(3):211-213.
doi: 10.1016/j.pt.2024.02.002. Epub 2024 Feb 16.

A promising pipeline of preclinical drug candidates for leishmaniasis and chronic Chagas' disease

Manuel Saldivia  1 , Ana Paula C A Lima  2 , Jeremy C Mottram  3
Affiliations
Free article

A promising pipeline of preclinical drug candidates for leishmaniasis and chronic Chagas' disease

Manuel Saldivia et al. Trends Parasitol. 2024 Mar.
Free article

Abstract

The drug discovery pipeline for leishmaniasis and trypanosomiasis has been filling with novel chemical entities with known mechanisms of action. González et al. and Braillard et al. report a cytochrome bc1 complex inhibitor as another promising preclinical candidate for visceral leishmaniasis (VL) and, in combination with benznidazole, for chronic Chagas' disease (CCD).

Keywords: chronic Chagas’ disease; cytochrome b; drug combinations; visceral leishmaniasis.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.