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. 2024 Jan 30;10(4):e25497.
doi: 10.1016/j.heliyon.2024.e25497. eCollection 2024 Feb 29.

Effect of different acupuncture sequences of Huiyangjiuzhen acupoints on blood glucose and hemorheology in the anesthetized rabbits

Peiying Pang  1 , Shen Zhuang  1 , Jiaqi Liu  1 , Li-Jen Chang  2 , Haoyan Yang  1 , Xiaoyu Fan  1 , Jie Mi  3 , Yongjun Zhang  4 , Yunpeng Fan  1 , Yingqiu Liu  1 , Weimin Zhang  1 , Wuren Ma  1   3
Affiliations

Effect of different acupuncture sequences of Huiyangjiuzhen acupoints on blood glucose and hemorheology in the anesthetized rabbits

Peiying Pang et al. Heliyon. .

Abstract

Background and objective: Hemorheology and blood glucose are commonly used to estimate the risks of thrombosis and stress hyperglycemia after anaesthesia. The sequence of acupoint stimulation might influence the therapeutic effects of acupuncture. In the current study, we aimed at investigating the effect of different acupuncture sequences of "Huiyangjiuzhen" acupoints on the blood glucose and hemorheology in anesthetized rabbits.

Methods: Twenty-five rabbits were randomly divided into five groups, including the control group (CG), the positive-sequence group (PSG), the reverse-sequence group (RSG), the disorder-sequence group (DSG), and the random group (RG). Except for the CG and RG, the rabbits in other groups were acupunctured with different sequences of "Huiyangjiuzhen"acupoints when the rabbits were anesthetized. The acupoints in rabbits of the RG were chosen randomly. The levels of blood glucose and hemorheology indexes before and after anaesthesia was detected.

Results: In the PSG, Hηb 200/s, Mηb 30/s, Hηr 200/s, ERI, hematocrit and plasma viscosity levels were decreased, and the blood glucose level was not changed. In the DSG, the levels of Mηb 30/s and hematocrit were decreased, and the blood glucose was increased. In the CG, RSG and RG, no hemorheology indexes were changed and the blood glucose was increased.

Conclusion: "Huiyangjiuzhen" acupuncture could decrease the risks of post-operative thrombosis and stress hyperglycemia in anesthetized rabbits. This effectiveness depends on both acupuncture and acupuncture sequence at the "Huiyangjiuzhen" acupoints.

Keywords: Acupuncture sequence; Blood glucose; General anaesthesia; Hemorheology; Huiyangjiuzhen.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
The influence of different acupoint intervention sequence of “Huiyangjiuzhen” acupuncture on the whole blood viscosity. The levels of Hηb 200/s before and after anaesthesia (a), the levels of Mηb 30/s before and after anaesthesia (b), the levels of Lηb 1/s before and after anaesthesia (c), The levels of Hηr 200/s before and after anaesthesia (d),the levels of Mηr 30/s before and after anaesthesia (e),the levels of Lηr 1/s before and after anaesthesia (f). Each value is expressed as the mean ± SEM. The numerical value represents the difference between before and after anaesthesia in the same group.
Fig. 2
Fig. 2
The influence of different acupoint intervention sequence of “Huiyangjiuzhen” acupuncture on the erythrocyte functions. The levels of EDI before and after anaesthesia (a), the levels of EAI before and after anaesthesia (b), the levels of ERI before and after anaesthesia (c), the levels of hematocrit before and after anaesthesia (d). Each value is expressed as the mean ± SEM. The numerical value represents the difference between before and after anaesthesia in the same group.
Fig. 3
Fig. 3
The influence of different acupoint intervention sequence of “Huiyangjiuzhen” acupuncture on the levels of plasma viscosity before and after anaesthesia. Each value is expressed as the mean ± SEM. The numerical value represents the difference between before and after anaesthesia in the same group.
Fig. 4
Fig. 4
The influence of different acupoint intervention sequence of “Huiyangjiuzhen” acupuncture on the levels of fibrinogen before and after anaesthesia. Each value is expressed as the mean ± SEM. The numerical value represents the difference between before and after anaesthesia in the same group.
Fig. 5
Fig. 5
The influence of different acupoint intervention sequence of “Huiyangjiuzhen” acupuncture on the levels of blood glucose. Each value is expressed as the mean ± SEM. The numerical value represents the difference between before and after anaesthesia in the same group.
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