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Case Reports
. 2024 Jan 18;16(1):e52479.
doi: 10.7759/cureus.52479. eCollection 2024 Jan.

Regression of Multiple Intracranial Meningiomas With Cessation of Progesterone Agonist Therapy: A Case Report

David S Bailey  1 , Kevin John  2 , Lekhaj C Daggubati  3 , Brad E Zacharia  1
Affiliations
Case Reports

Regression of Multiple Intracranial Meningiomas With Cessation of Progesterone Agonist Therapy: A Case Report

David S Bailey et al. Cureus. .

Abstract

In this case report, we discuss a patient who experienced spontaneous regression of multiple intracranial meningiomas that were treated conservatively for 5 years after cessation of megestrol acetate, an exogenous progestin. In addition, we discuss the previous literature describing the relationship between exogenous progesterone medications and meningioma growth. This case, along with others reported, implies that cessation of progesterone therapy, when feasible, may alter the natural history of meningioma growth and thus impact treatment decisions.

Keywords: extra-axial lesion; hormonal influence on meningioma; megestrol acetate; meningioma; progestin.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Initial T1 post-contrast MRI.
Axial, coronal, and sagittal images demonstrating (A) left sphenoid meningioma (14.9 cc), (B) planum sphenoidale meningioma (1.9 cc), and (C) left lateral sphenoid wing meningioma (0.3 cc). MRI, magnetic resonance imaging
Figure 2
Figure 2. Two-year follow-up CT scan with contrast.
Decreased size of (A) left sphenoid, (B) planum sphenoidale, and (C) left lateral sphenoid wing meningioma. CT, computed tomography
Figure 3
Figure 3. Five-year follow-up T1 non-contrasted MRI of the brain.
Decreasing size of all three meningiomas: (A) left sphenoid, (B) planum sphenoidale, and (C) left lateral sphenoid wing. MRI, magnetic resonance imaging
See this image and copyright information in PMC

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