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Review
. 2024 Feb 13:15:13-24.
doi: 10.2147/RRTM.S397138. eCollection 2024.

An Update on the Pathogenesis of Fascioliasis: What Do We Know?

Melinda B Tanabe  1 , Maria A Caravedo  1 , A Clinton White Jr  1   2 , Miguel M Cabada  1   2
Affiliations
Review

An Update on the Pathogenesis of Fascioliasis: What Do We Know?

Melinda B Tanabe et al. Res Rep Trop Med. .

Abstract

Fasciola hepatica is a trematode parasite distributed worldwide. It is known to cause disease in mammals, producing significant economic loses to livestock industry and burden to human health. After ingestion, the parasites migrate through the liver and mature in the bile ducts. A better understanding of the parasite's immunopathogenesis would help to develop efficacious therapeutics and vaccines. Currently, much of our knowledge comes from in vitro and in vivo studies in animal models. Relatively little is known about the host-parasite interactions in humans. Here, we provide a narrative review of what is currently know about the pathogenesis and host immune responses to F. hepatica summarizing the evidence available from the multiple hosts that this parasite infects.

Keywords: Fasciola spp; immunological response; infection; pathogenesis.

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Conflict of interest statement

The authors have no financial or conflicts of interest to disclose for this work.

Figures

Figure 1
Figure 1
Immune response to fascioliasis depending on the phase of the infection. (Illustration created with BioRender.com).,
Figure 2
Figure 2
Immunomodulatory effects of the excretory/secretory and tegumental antigens in Fasciola hepatica (Illustration created with BioRender.com).,,
See this image and copyright information in PMC

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