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Review
. 2023 Dec 27:16:299-305.
doi: 10.1016/j.aninu.2023.12.004. eCollection 2024 Mar.

Diarrhea induced by insufficient fat absorption in weaned piglets: Causes and nutrition regulation

Yuying Li  1 , Pengjun Shi  1 , Kang Yao  2 , Qian Lin  1 , Mansheng Wang  1 , Zhenping Hou  1 , Wenjie Tang  3 , Hui Diao  3
Affiliations
Review

Diarrhea induced by insufficient fat absorption in weaned piglets: Causes and nutrition regulation

Yuying Li et al. Anim Nutr. .

Abstract

Fat is one of the three macronutrients and a significant energy source for piglets. It plays a positive role in maintaining intestinal health and improving production performance. During the weaning period, physiological, stress and diet-related factors influence the absorption of fat in piglets, leading to damage to the intestinal barrier, diarrhea and even death. Signaling pathways, such as fatty acid translocase (CD36), pregnane X receptor (PXR), and AMP-dependent protein kinase (AMPK), are responsible for regulating intestinal fat uptake and maintaining intestinal barrier function. Therefore, this review mainly elaborates on the reasons for diarrhea induced by insufficient fat absorption and related signaling pathways in weaned-piglets, with an emphasis on the intestinal fat absorption disorder. Moreover, we focus on introducing nutritional strategies that can promote intestinal fat absorption in piglets with insufficient fat absorption-related diarrhea, such as lipase, amino acids, and probiotics.

Keywords: Diarrhea; Fat absorption; Nutrient regulation; Weaned piglet.

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Conflict of interest statement

We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, and there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the content of this paper.

Figures

Fig. 1
Fig. 1
Reasons of fat absorption disorders in weaned piglets.
Fig. 2
Fig. 2
Fatty acids uptake through CD36, PXR, and AMPK signaling pathways. CD36 = fatty acid translocase; PXR = pregnane X receptor; AMPK = AMP-dependent protein kinase; FATPs = fatty acid transport proteins; FABPs = fatty acid binding proteins.
See this image and copyright information in PMC

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