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. 2024 Feb 2;6(1):100343.
doi: 10.1016/j.infpip.2024.100343. eCollection 2024 Mar.

Epidemiological differences, clinical aspects, and short-term prognosis of patients with healthcare-associated and community-acquired infective endocarditis

Juliana Barros Becker  1 , Valdir Ambrósio Moisés  2 , María Dolores Guerra-Martín  3 , Dulce Aparecida Barbosa  4
Affiliations

Epidemiological differences, clinical aspects, and short-term prognosis of patients with healthcare-associated and community-acquired infective endocarditis

Juliana Barros Becker et al. Infect Prev Pract. .

Abstract

Background: The prevalence of healthcare-associated infective endocarditis in Brazil is poorly known.

Aim: To analyze the epidemiological, clinical and microbiological characteristics, and the prognosis of healthcare-associated infective endocarditis (HAIE) compared with community-acquired infective endocarditis (CIE) and identify the associated factors with hospital mortality.

Method: A historical cohort study was carried out, with a data collection period from January 2009 to December 2019 at the Federal University of São Paulo. Data were collected from medical records of patients with infective endocarditis (IE) hospitalized during the study period. Patients were classified into three groups: CIE, non-nosocomial HAIE (NN-HAIE) and nosocomial HAIE (NHAIE).

Results: A total of 204 patients with IE were included; of these, 127 (62.3%) were cases of HAIE, of which 83 (40.7%) were NN-HAIE and 44 (21.6%) were NHAIE. Staphylococcus spp. Were the main causative agents, especially in HAIE groups (P<0.001). Streptococcus spp. were more prevalent in the CIE group (P<0.001). In-hospital mortality was 44.6%, with no differences between groups. Independent risk factors for in-hospital mortality were age ≥ 60 years (odds ratio (OR): 6.742), septic shock (OR 5.264), stroke (OR 3.576), heart failure (OR 7.296), and Intensive Care Unit admission (OR 7.768).

Conclusion: HAIE accounted for most cases in this cohort, with a higher prevalence of non-nosocomial infections. Staphylococcus spp. were the main causative agents. Hospital mortality was high, 44.6%, with no difference between groups.

Keywords: Community-acquired; Epidemiology; Healthcare-associated infections; Hospital mortality; Infective endocarditis; Meticillin-resistant Staphylococcus aureus; Staphylococcus.

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Figures

Figure 1
Figure 1
Etiologic IE agents in patients with CIE and HAIE.
See this image and copyright information in PMC

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