doi: 10.1128/mcb.5.9.2487-2490.1985.
The spliced leader sequence of Trypanosoma brucei has a potential role as a cap donor structure
- PMID: 3837191
- PMCID: PMC366976
- DOI: 10.1128/mcb.5.9.2487-2490.1985
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The spliced leader sequence of Trypanosoma brucei has a potential role as a cap donor structure
Mol Cell Biol.
1985 Sep.
Abstract
Trypanosoma brucei brucei and other trypanosomatid species are unique among eucaryotes because transcription of their protein-coding genes is discontinuous. The 5' ends of their mRNAs consist of an identical 35-nucleotide spliced leader which is encoded at a separate locus from that for the body of the protein-coding transcript. We show here that the spliced leader transcript contains a 5' cap structure and suggest that at least one function of the spliced leader sequence is to provide a cap structure to trypanosome mRNAs.
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