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Meta-Analysis
. 2024 Jan-Dec:23:15347354241233226.
doi: 10.1177/15347354241233226.

Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis

Hye-Ri Bae  1 , Eun-Ji Kim  1 , Yo-Chan Ahn  2 , Jung-Hyo Cho  3 , Chang-Gue Son  3 , Nam-Hun Lee  1
Affiliations
Meta-Analysis

Efficacy of Moxibustion for Cancer-Related Fatigue in Patients with Breast Cancer: A Systematic Review and Meta-Analysis

Hye-Ri Bae et al. Integr Cancer Ther. 2024 Jan-Dec.

Abstract

Introduction: Breast cancer is the most commonly diagnosed cancer worldwide, and most patients experience fatigue. However, there are no effective treatments for cancer-related fatigue (CRF). Several randomized controlled trials (RCTs) have suggested that moxibustion improves CRF. We conducted a systematic review and meta-analysis to compare the differences in fatigue scale scores, quality of life, and clinical efficacy in patients with breast cancer who developed CRF and did versus did not receive moxibustion.

Methods: RCTs were searched in 7 databases using a standardized search method from database inception to March 2023, and RCTs that met the inclusion criteria were selected.

Results: Among 1337 initially identified RCTs, 10 RCTs involving 744 participants were selected for this study. The meta-analysis involved assessment of the revised Piper Fatigue Scale scores, Cancer Fatigue Scale scores, Karnofsky Performance Scale scores, Athens Insomnia Scale scores, clinical efficacy, and Qi deficiency syndrome scale scores. Compared with the control, moxibustion was associated with significantly better Piper Fatigue Scale scores (P < 0.0001), quality of life [Karnofsky Performance Scale scores (P < 0.0001)], clinical efficacy (P = 0.0007), and Qi deficiency syndrome scale scores (P = 0.02).

Conclusions: Moxibustion improves CRF in patients with breast cancer. The efficacy of moxibustion should be further examined by high-quality studies in various countries with patients subdivided by their breast cancer treatment status.

Registration: PROSPERO ID: CRD42023451292.

Keywords: breast cancer; cancer-related fatigue; fatigue; meta-analysis; moxibustion.

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Conflict of interest statement

Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Flow chart of the study selection process for the meta-analysis.
Figure 2.
Figure 2.
Risk of bias summary.
Figure 3.
Figure 3.
Risk of bias graph.
Figure 4.
Figure 4.
Comparison of revised Piper Fatigue Scale between the moxibustion group and control group.
Figure 5.
Figure 5.
Comparison of Cancer Fatigue Scale between the moxibustion group and control group.
Figure 6.
Figure 6.
Comparison of Karnofsky Performance Scale between the moxibustion group and control group.
Figure 7.
Figure 7.
Comparison of Athens Insomnia Scale score between the moxibustion group and control group.
Figure 8.
Figure 8.
Comparison of clinical efficacy between the moxibustion group and control group.
Figure 9.
Figure 9.
Comparison of Qi deficiency syndrome scale between the moxibustion group and control group.
See this image and copyright information in PMC

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