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. 2024 Jun 1;51(6):431-436.
doi: 10.1097/OLQ.0000000000001951. Epub 2024 Feb 19.

Sexually Transmitted Infection Prevalence, Partner Notification, and Human Immunodeficiency Virus Risk Perception in a Cohort of Women Completing Sexually Transmitted Infection Screening as Part of a Safer Conception Study

Ivana Beesham  1 , Oluwaseyi Isehunwa  2 , Yolandie Kriel  1 , Manjeetha Jaggernath  1 , Kara Bennett  3 , Kathleen Hurwitz  3 , Patricia M Smith  2 , Pooja Chitneni  4 , Shannon Bosman  5 , David R Bangsberg  6 , Jeanne M Marrazzo  2 , Jennifer A Smit  1 , Lynn T Matthews  2
Affiliations

Sexually Transmitted Infection Prevalence, Partner Notification, and Human Immunodeficiency Virus Risk Perception in a Cohort of Women Completing Sexually Transmitted Infection Screening as Part of a Safer Conception Study

Ivana Beesham et al. Sex Transm Dis. .

Abstract

Background: Integrating sexually transmitted infection (STI) and preexposure prophylaxis (PrEP) care may optimize sexual and reproductive health.

Methods: We nested an STI substudy within a human immunodeficiency virus (HIV) prevention cohort (parent study) of 18- to 35-year-old women from South Africa, planning pregnancy with a partner with HIV or of unknown serostatus. Parent-study women completed annual surveys regarding HIV-risk perceptions and were offered oral PrEP. Preexposure prophylaxis initiators completed quarterly plasma tenofovir (TFV) testing. Substudy women completed STI screening at enrollment, 6 months, onset of pregnancy, and in the third trimester via examination, vaginal swabs tested via PCR for Chlamydia trachomatis , Neisseria gonorrhoeae , Trichomonas vaginalis , Mycoplasma genitalium , and blood tested for Treponema pallidum . Follow-up was 6 months. Women with STIs were treated, offered partner notification (PN) cards, and surveyed regarding PN practices. We describe STI prevalence and incidence, and model factors associated with prevalent infection. Sexually transmitted infection substudy and parent study-only participants were matched on age and number of days on study to assess HIV-risk perception scores between the 2 groups and the proportion with detectable TFV.

Results: Among 50 substudy participants, 15 (30%) had prevalent STI. All 13 completing follow-up reported PN. Most did not prefer assisted PN. Mean HIV risk perception scores and proportion with detected plasma TFV were similar across groups.

Conclusions: High STI prevalence supports the importance of laboratory screening to optimize sexual health for women planning pregnancy. Rates of self-reported PN are reassuring; low interest in assisted PN suggests the need for alternative approaches. Enhanced STI care did not affect HIV-risk perception or PrEP adherence, however both were relatively high in this cohort.

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Conflict of interest statement

Conflict of interest: Gilead Sciences provided operational support and study drug for the parent study.

References

    1. UNAIDS. Country fact sheets: South Africa (2021). [cited 2022 December, 08]. Available from: https://www.unaids.org/en/regionscountries/countries/southafrica . Accessed April 29, 2024.
    1. Kim H-Y, Harling G, Vandormael A, et al. HIV seroconcordance among heterosexual couples in rural KwaZulu-Natal, South Africa: A population-based analysis. J Int AIDS Soc 2020; 23:e25432.
    1. Simbayi LCZK, Zungu N, Moyo S, et al. South African National HIV prevalence, incidence. Behaviour and Communication Survey 2017; Cape Town 2019.
    1. Thomson KA, Hughes J, Baeten JM, et al. Increased risk of HIV acquisition among women throughout pregnancy and during the postpartum period: A prospective per-coital-act analysis among women with HIV-infected partners. J Infect Dis 2018; 218:16–25.
    1. Ahmadi MH, Mirsalehian A, Bahador A. Association of Chlamydia trachomatis with infertility and clinical manifestations: A systematic review and meta-analysis of case-control studies. Infect Dis (Lond) 2016; 48:517–523.

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