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Review
. 2024 Feb 19;150(2):96.
doi: 10.1007/s00432-024-05623-7.

Current look at the most promising proteomic and glycomic biomarkers of bladder cancer

Stefan Harsanyi  1 , Kristina Kianickova  2 , Jaroslav Katrlik  2 , Lubos Danisovic  3 , Stanislav Ziaran  4
Affiliations
Review

Current look at the most promising proteomic and glycomic biomarkers of bladder cancer

Stefan Harsanyi et al. J Cancer Res Clin Oncol. .

Abstract

Background: Bladder cancer (BC) belongs to the most frequent cancer types. The diagnostic process is still long and costly, with a high percentage of false-positive or -negative results. Due to the cost and lack of effectiveness, older methods need to be supplemented or replaced by a newer more reliable method. In this regard, proteins and glycoproteins pose high potential.

Methods: We performed an online search in PubMed/Medline, Scopus, and Web of Science databases to find relevant studies published in English up until May 2023. If applicable, we set the AUC threshold to 0.90 and sensitivity/specificity (SN/SP) to 90%.

Findings: Protein and glycoprotein biomarkers are a demonstrably viable option in BC diagnostics. Cholinesterase shows promise in progression-free survival. BLCA-4, ORM-1 along with HTRA1 in the detection of BC. Matrix metallopeptidase 9 exhibits potential for stratification of muscle-invasive subtypes with high negative predictive value for aggressive phenotypes. Distinguishing non-muscle invasive subtypes benefits from Keratin 17. Neu5Gc-modified UMOD glycoproteins pose potential in BC diagnosis, while fibronectin, laminin-5, collagen type IV, and lamprey immunity protein in early detection of BC.

Keywords: Biomarkers; Bladder cancer; Diagnostics; Glycoprotein; Protein.

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Conflict of interest statement

The authors declare no potential conflicts of interest concerning the research, authorship, and/or publication of this article.

Figures

Fig. 1
Fig. 1
Association of proteomic and glycomic markers with BC diagnosis
See this image and copyright information in PMC

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