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Observational Study
. 2024 Jun;43(3):660-667.
doi: 10.1007/s12664-023-01496-9. Epub 2024 Feb 19.

Clinical profile of 1208 newly diagnosed colorectal cancer patients in Tamil Nadu-A multi-centric survey

Ebby George Simon  1 , Ubal Dhus  2 , Amara Sadguna Rao  2 , Kannan M  3 , Kondala Rao Yedupati  3 , John Titus George  4 , Premkumar K  5 , Anupama Swarna  5 , Aravindh Somasundaram  6 , Arulraj Ramakrishnan  6 , Venkatakrishnan L  7 , Dhanush Thomas  7 , Arulselvan V  8 , Arshiya Mubin S P  8 , Revathy M S  9 , Rakesh Jha  9 , Jeswanth S  10 , Satish Devakumar  10 , Alagammai Pl  11 , Sujata V Gade  11 , Kanagavel Manickavasagam  12 , Deepak Agarwal  12 , Mohan Prasad V G  13 , Madhura Prasad  13 , Mahadevan B  14 , Dinu Abirami  14 , Chandrasekar T S  15 , Gokul B J  15 , Rajesh Natrayan  16 , Harshini Manonmani Sampathkumar  16 , Ramakrishna B S  17 , Naveen Chand  17 , Joseph Jensingh Babu S  18 , Sindhu Ashokan  18 , Arulprakash S  19 , Karishma Srinivasan  19 , Aravind A  20 , Lavanya N  20 , Arun R S  21 , Asher Edward Prem Kumar  21 , Rathnaswami A  22 , Rajesh N A  23 , Arun A C  24 , Ganga Balaji  24 , Padmanabhan P  25 , Somnath Verma  25 , Jayanthi V  26
Affiliations
Observational Study

Clinical profile of 1208 newly diagnosed colorectal cancer patients in Tamil Nadu-A multi-centric survey

Ebby George Simon et al. Indian J Gastroenterol. 2024 Jun.

Abstract

Background: An increasing incidence of colorectal cancer (CRC) is being reported in developing countries, including India. Most Indian studies on CRC are retrospective and single-centered. The present study is an attempt to understand the current clinical profile and stage of newly diagnosed CRCs across multiple centers in Tamil Nadu, India.

Methods: A multi-centric observational survey was conducted between September 1, 2021, and August 31, 2022, under the aegis of the Indian Society of Gastroenterology - Tamil Nadu chapter. Patients 18 years of age and older with a recent diagnosis of CRC fulfilling the inclusion criteria were prospectively recruited at the participating centers. Their demographic, clinical, biochemical, endoscopic, histopathologic, radiologic and risk factor details were systematically collected and analyzed.

Results: Across 23 centers in Tamil Nadu, 1208 patients were recruited. The male:female ratio was 1.49:1, while mean (SD) age was 57.7 (13.5) years. A majority (81.9%) were Tamils and 78.5% belonged to lower socioeconomic classes. The predominant symptoms were hematochezia (30.2%) and a change in bowel habits (27.5%). The most common locations were the rectum (34.3%) and rectosigmoid (15.1%). Synchronous CRCs were seen in 3.3% and synchronous colorectal polyps in 12.8%. Predisposing factors for CRC were seen in 2%. A past history of any cancer among CRC patients was obtained in 3.1% and a family history of any cancer was found in 7.6%. Patients who were either overweight or obese constituted 46.4% of the study population. At presentation, the predominant stages were stage III (44.7%) and stage IV (20.8%).

Conclusions: A majority of patients with newly diagnosed CRC in Tamil Nadu belonged to the lower socioeconomic classes. About 60% had CRCs located within the reach of the flexible sigmoidoscope. Two-thirds of the patients exceeded stage II disease at presentation.

Trial registration: Not applicable.

Keywords: Clinical profile; Colorectal cancer; Demography; Endoscopy; Epidemiology; India; Newly diagnosed cancer; Risk factors; Staging; Tamil Nadu.

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