Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2024 Feb 12;44(2):144-148.
doi: 10.13703/j.0255-2930.20230409-0004.

Heat-sensitive moxibustion combined with Xiangwu powder for erectile dysfunction with kidney deficiency and blood stasis: a randomized controlled trial

[Article in English, Chinese]
Wuzhi Gao  1 , Zixue Sun  2 , Xiang Chen  1 , Pengchao Li  1 , Xinghua Zhang  1 , Jianshe Chen  1 , Liyan Geng  1 , Chenming Zhang  1
Affiliations
Randomized Controlled Trial

Heat-sensitive moxibustion combined with Xiangwu powder for erectile dysfunction with kidney deficiency and blood stasis: a randomized controlled trial

[Article in English, Chinese]
Wuzhi Gao et al. Zhongguo Zhen Jiu. .

Abstract
in English, Chinese

Objectives: To observe the clinical efficacy of heat-sensitive moxibustion combined with Xiangwu powder in treating erectile dysfunction with kidney deficiency and blood stasis.

Methods: A total of 80 patients with erectile dysfunction of kidney deficiency and blood stasis were randomly divided into a comprehensive group (40 cases, 1 case dropped out) and a Chinese herb group (40 cases, 2 cases dropped out). In the Chinese herb group, Xiangwu powder was applied orally, one dose per day. On the basis of the Chinese herb group, heat-sensitive moxibustion was applied after detecting the heat-sensitive points in the areas of Guanyuan (CV 4), Zhongji (CV 3), Qihai (CV 6) and bilateral Xuehai (SP 10), Sanyinjiao (SP 6) in the comprehensive group, once a day, 5 times a week. Both groups were treated for 4 weeks. The international index of erectile function-5 (IIEF-5) score, erectile hardness score (EHS), nocturnal penile tumescence and rigidity (NPTR) indexes (nocturnal penile erection frequency, total duration of penile erection, duration of penile head hardness ≥60%, duration of penile root hardness ≥60%, percentage change in penile head circumference, percentage change in penile root circumference), TCM syndrome score, and penile vascular function indexes (peak systolic velocity [PSV], end diastolic velocity [EDV], and resistance index [RI] of penile cavernosal artery) were compared in the patients of the two groups before and after treatment, and the clinical efficacy was evaluated.

Results: After treatment, the IIEF-5 scores, EHS, PSV, RI, and NPTR indexes were increased compared with those before treatment (P<0.01), while the TCM syndrome scores and EDV were decreased compared with those before treatment (P<0.01) in the two groups.The IIEF-5 score, EHS, PSV, RI, and NPTR indexes in the comprehensive group were ascended compared with those in the Chinese herb group (P<0.01), while the TCM syndrome score and EDV in the comprehensive group were lower than those in the traditional Chinese herb group (P<0.01). The total effective rate of the comprehensive group was 94.9% (37/39), which was higher than 78.9% (30/38, P<0.05) of the Chinese herb group.

Conclusions: The combination of heat-sensitive moxibustion and Xiangwu powder can effectively treat erectile dysfunction of kidney deficiency and blood stasis, improve patients' erectile function, enhance their erection hardness, and improve their penile vascular function and clinical symptoms.

目的: 观察热敏灸联合香蜈散治疗肾虚血瘀型勃起功能障碍的临床疗效。方法: 将80例肾虚血瘀型勃起功能障碍患者随机分为综合组（40例，脱落1例）和中药组（40例，脱落2例）。中药组口服香蜈散治疗，每日1剂，治疗4周；综合组在中药组基础上于关元、中极、气海及双侧血海、三阴交穴区探寻热敏腧穴行热敏灸治疗，每日1次，每周5次，治疗4周。分别于治疗前后观察两组患者勃起功能国际问卷-5（IIEF-5）评分、勃起硬度评分（EHS）、夜间阴茎勃起硬度监测（NPTR）指标［夜间阴茎勃起次数、阴茎勃起总持续时间、阴茎头部硬度≥60%持续时间、阴茎根部硬度≥60% 持续时间、阴茎头部周径变化百分比、阴茎根部周径变化百分比］、中医证候积分、阴茎血管功能指标［阴茎海绵体动脉收缩期峰值流速（PSV）、舒张末期流速（EDV）、阻力指数（RI）］，并评定两组临床疗效。结果: 治疗后，两组患者IIEF-5评分、EHS、PSV、RI及NPTR指标均较治疗前升高（P<0.01），中医证候积分及EDV均较治疗前降低（P<0.01）；综合组患者IIEF-5评分、EHS、PSV、RI及NPTR指标均高于中药组（P<0.01），中医证候积分及EDV均低于中药组（P<0.01）。综合组总有效率为94.9%（37/39），高于中药组的78.9%（30/38，P<0.05）。结论: 热敏灸联合香蜈散可有效治疗肾虚血瘀型勃起功能障碍，改善患者勃起功能，提高其勃起硬度，改善其阴茎血管功能与临床症状。.

Keywords: Xiangwu powder; erectile dysfunction, kidney deficiency and blood stasis; heat-sensitive moxibustion; randomized controlled trial (RCT).

PubMed Disclaimer

References

    1. 秦国政. 中医男科学[M]. 北京: 科学出版社, 2017: 138- 141.
    1. Goldstein I, Goren A, Li VW, et al. Epidemiology update of erectile dysfunction in eight countries with high burden[J]. Sex Med Rev, 2020, 8(1): 48- 58.
    1. 杨绍威, 康春卯, 赵辉, 等. 男性勃起功能障碍发生的影响因素及列线图风险模型的构建[J]. 中国性科学, 2023, 32(6): 44- 48.
    1. 曹志琴, 杜海亮, 吴志萍, 等. 勃起功能障碍患者疾病感知及影响因素调查分析[J]. 中国男科学杂志, 2023, 37(1): 85- 89.
    1. 李鹏超, 孙自学, 陈翔, 等. 益肾疏肝起痿方联合针灸治疗重度功能性勃起功能障碍的临床研究[J]. 时珍国医国药, 2022, 33(5): 1149- 1151.

Publication types

LinkOut - more resources