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. 2024 Feb 19;24(1):129.
doi: 10.1186/s12887-024-04596-3.

The association between sex and neonatal respiratory distress syndrome

Keren Fang  1 , Shaojie Yue  1 , Shuo Wang  1 , Mingjie Wang  1 , Xiaohe Yu  1 , Ying Ding  1 , Mei Lv  1 , Yang Liu  1 , Chuanding Cao  2 , Zhengchang Liao  3
Affiliations

The association between sex and neonatal respiratory distress syndrome

Keren Fang et al. BMC Pediatr. .

Abstract

Background: To investigate the association between sex and neonatal respiratory distress syndrome (NRDS).

Methods: Neonates born at our hospital and transferred to the neonatal department within 1 h were retrospectively analyzed. Depending on whether they developed NRDS during their hospital stay, the neonates was divided into NRDS and non-NRDS groups. There were 142 neonates in the NRDS group (95 males and 47 females) and 310 neonates in the non-NRDS group (180 males and 140 females). The neonates' data on gestational age (GA), sex, birth weight, white blood cell count (WBC), platelet count (PLT), C-reactive protein (CRP), total immunoglobulin M (total IgM), gestational diabetes mellitus(GDM), antenatal steroids use, meconium-stained amniotic fluid, and preterm premature rupture of membranes(PPROM) were gathered.

Results: 452 neonates (265 males and 187 females) were involved for the purpose of collecting basic characteristic. Multivariate analysis, males had a 1.87 times higher risk of NRDS than females (P < 0.05) after controlling for the confounding effects of GA, birth weight, WBC, PLT, CRP, total IgM, GDM, antenatal steroids use, meconium-stained amniotic fluid, and PPROM.

Conclusions: Sex was associated with NRDS; males had a considerably higher risk of NRDS than females.

Keywords: Logistic regression; Neonate; Respiratory distress syndrome; Risk; Sex.

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Conflict of interest statement

The authors declare no competing interests.

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