The All of Us Research Program is an opportunity to enhance the diversity of US biomedical research

Diana W Bianchi¹, Patricia Flatley Brennan^{2

3}, Michael F Chiang⁴, Lindsey A Criswell⁵, Rena N D'Souza⁶, Gary H Gibbons⁷, James K Gilman⁸, Joshua A Gordon⁹, Eric D Green¹⁰, Susan Gregurick¹¹, Richard J Hodes¹², Peter H Kilmarx¹³, George F Koob¹⁴, Walter J Koroshetz¹⁵, Helene M Langevin¹⁶, Jon R Lorsch¹⁷, Jeanne M Marrazzo¹⁸, Eliseo J Pérez-Stable¹⁹, W Kimryn Rathmell²⁰, Griffin P Rodgers²¹, Joni L Rutter²², Jane M Simoni²³, Bruce J Tromberg²⁴, Debara L Tucci²⁵, Nora D Volkow²⁶, Rick Woychik²⁷, Shannon N Zenk²⁸, Elyse Kozlowski²⁹, Rachele S Peterson²⁹, Geoffrey S Ginsburg²⁹, Joshua C Denny³⁰

Affiliations

¹ Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
² National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
³ , Easton, MD, USA.
⁴ National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
⁵ National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
⁶ National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
⁷ National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
⁸ Clinical Center, National Institutes of Health, Bethesda, MD, USA.
⁹ National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
¹⁰ National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
¹¹ Office of Data Science Strategy, National Institutes of Health, Bethesda, MD, USA.
¹² National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
¹³ Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
¹⁴ National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
¹⁵ National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
¹⁶ National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD, USA.
¹⁷ National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD, USA.
¹⁸ National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
¹⁹ National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA.
²⁰ National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
²¹ National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
²² National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
²³ Offices of the Director and Behavioral and Social Sciences Research, National Institutes of Health, Bethesda, MD, USA.
²⁴ National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.
²⁵ National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
²⁶ National Institute of Drug Abuse, National Institutes of Health, Bethesda, MD, USA.
²⁷ National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
²⁸ National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.
²⁹ All of Us Research Program, National Institutes of Health, Bethesda, MD, USA.
³⁰ All of Us Research Program, National Institutes of Health, Bethesda, MD, USA. joshua.denny@nih.gov.

PMID: 38374344
PMCID: PMC11835384
DOI: 10.1038/s41591-023-02744-3

The All of Us Research Program is an opportunity to enhance the diversity of US biomedical research

Diana W Bianchi et al. Nat Med. 2024 Feb.

. 2024 Feb;30(2):330-333.

doi: 10.1038/s41591-023-02744-3.

Authors

Affiliations

¹ Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
² National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
³ , Easton, MD, USA.
⁴ National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
⁵ National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
⁶ National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
⁷ National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
⁸ Clinical Center, National Institutes of Health, Bethesda, MD, USA.
⁹ National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
¹⁰ National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
¹¹ Office of Data Science Strategy, National Institutes of Health, Bethesda, MD, USA.
¹² National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
¹³ Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
¹⁴ National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
¹⁵ National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
¹⁶ National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD, USA.
¹⁷ National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD, USA.
¹⁸ National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
¹⁹ National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA.
²⁰ National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
²¹ National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
²² National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.
²³ Offices of the Director and Behavioral and Social Sciences Research, National Institutes of Health, Bethesda, MD, USA.
²⁴ National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.
²⁵ National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
²⁶ National Institute of Drug Abuse, National Institutes of Health, Bethesda, MD, USA.
²⁷ National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
²⁸ National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.
²⁹ All of Us Research Program, National Institutes of Health, Bethesda, MD, USA.
³⁰ All of Us Research Program, National Institutes of Health, Bethesda, MD, USA. joshua.denny@nih.gov.

PMID: 38374344
PMCID: PMC11835384
DOI: 10.1038/s41591-023-02744-3

Abstract

The All of Us Research Program has prioritized the enrollment of people from backgrounds historically underrepresented in medical research to bring precision medicine to the full diversity of the US population and to improve health outcomes for all.

PubMed Disclaimer

Conflict of interest statement

Competing interests

The authors declare no conflicts of interest.

Figures

**Figure 1.. Prevalence of common health conditions in the USA and among All of Us Research Program Participants.**
National prevalence of each disease is estimated by the Global Burden of Disease Study 2019. Utilizing the International Classification of Disease 9 (ICD-9) and the International Classification of Disease 10 (ICD-10) codes from the GBD2019 Study, mapped to OHDSI Common Data Model condition concepts, prevalence was estimated from participants who have provided access to their EHR records in All of Us, including the subset cohort identified as being Underrepresented Racial and Ethnic minorities in Biomedical Research. All estimates were adjusted to project predicted prevalence in 1 million people in the United States.

See this image and copyright information in PMC

References

1. Sudlow C. et al. PLoS Med 12, e1001779 (2015). - PMC - PubMed
1. Foreman KJ et al. Lancet 392, 2052–2090 (2018). - PMC - PubMed
1. Popejoy AB, Fullerton SM. Nature 538, 161–164 (2016). - PMC - PubMed
1. Mills MC, Rahal C. Nat Genet 52, 242–243 (2020). - PubMed
1. Martin AR et al. Nat Genet 51, 584–591 (2019). - PMC - PubMed

MeSH terms

Actions
Actions
Actions
Actions

Grants and funding

Z99 OD999999/ImNIH/Intramural NIH HHS/United States

LinkOut - more resources

Full Text Sources

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

The All of Us Research Program is an opportunity to enhance the diversity of US biomedical research

Affiliations

The All of Us Research Program is an opportunity to enhance the diversity of US biomedical research

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources