The involvement of serotonin in major depression: nescience in disguise?

Danilo Arnone^{1

2

3}, Toby Wise⁴, Paul B Fitzgerald⁵, Catherine J Harmer^{6

7}

Affiliations

¹ Department of Psychiatry, University of Ottawa, Ottawa, Canada. danilo.arnone@kcl.ac.uk.
² Centre for Affective Disorders, Psychological Medicine, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK. danilo.arnone@kcl.ac.uk.
³ Department of Mental Health, The Ottawa Hospital, Ottawa, Canada. danilo.arnone@kcl.ac.uk.
⁴ Department of Neuroimaging, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK.
⁵ School of Medicine and Psychology, College of Health and Medicine, The Australian National University, Canberra, Australia.
⁶ Department of Psychiatry, University of Oxford, Oxford, UK.
⁷ Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.

Comment

Danilo Arnone et al. Mol Psychiatry. 2024 Jan.

. 2024 Jan;29(1):200-202.

doi: 10.1038/s41380-024-02459-y. Epub 2024 Feb 19.

Danilo Arnone^{1

2

3}, Toby Wise⁴, Paul B Fitzgerald⁵, Catherine J Harmer^{6

7}

¹ Department of Psychiatry, University of Ottawa, Ottawa, Canada. danilo.arnone@kcl.ac.uk.
² Centre for Affective Disorders, Psychological Medicine, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK. danilo.arnone@kcl.ac.uk.
³ Department of Mental Health, The Ottawa Hospital, Ottawa, Canada. danilo.arnone@kcl.ac.uk.
⁴ Department of Neuroimaging, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK.
⁵ School of Medicine and Psychology, College of Health and Medicine, The Australian National University, Canberra, Australia.
⁶ Department of Psychiatry, University of Oxford, Oxford, UK.
⁷ Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.

No abstract available

Comment on

The serotonin theory of depression: a systematic umbrella review of the evidence.
Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA. Moncrieff J, et al. Mol Psychiatry. 2023 Aug;28(8):3243-3256. doi: 10.1038/s41380-022-01661-0. Epub 2022 Jul 20. Mol Psychiatry. 2023. PMID: 35854107 Free PMC article.

1. Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA. The serotonin theory of depression: a systematic umbrella review of the evidence. Mol Psychiatry. 2022. https://doi.org/10.1038/s41380-022-01661-0 .
1. Cowen PJ, Browning M. What has serotonin to do with depression? World Psychiatry. 2015;14:158–60. - DOI - PubMed - PMC
1. Beliveau V, Ozenne B, Strother S, Greve DN, Svarer C, Knudsen GM, et al. The structure of the serotonin system: a PET imaging study. NeuroImage. 2020;205:116240. - DOI - PubMed
1. Erritzoe D, Godlewska BR, Rizzo G, Searle GE, Agnorelli C, Lewis Y, et al. Brain serotonin release is reduced in patients with depression: a [11c]cimbi-36 pet study with a d-amphetamine challenge. Biol Psychiatry. 2022:S0006322322017048.
1. Murakami M, Mainen ZF. Preparing and selecting actions with neural populations: toward cortical circuit mechanisms. Curr Opin Neurobiol. 2015;33:40–46. - DOI - PubMed