Methodological concerns in umbrella review of serotonin and depression

Andrew L Smith^{1

2}, Andre F Carvalho³, Marco Solmi^{4

5

6

7

8}

Affiliations

¹ Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada. andrewlsmith@toh.ca.
² Department of Mental Health, The Ottawa Hospital, Ottawa, ON, Canada. andrewlsmith@toh.ca.
³ IMPACT (Innovation in Mental and Physical Health and Clinical Treatment) Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia.
⁴ Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada.
⁵ Department of Mental Health, The Ottawa Hospital, Ottawa, ON, Canada.
⁶ Ottawa Hospital Research Institute (OHRI) Clinical Epidemiology Program University of Ottawa, Ottawa, ON, Canada.
⁷ School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
⁸ Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.

Comment

Andrew L Smith et al. Mol Psychiatry. 2024 Jan.

. 2024 Jan;29(1):203-204.

doi: 10.1038/s41380-024-02460-5. Epub 2024 Feb 19.

Andrew L Smith^{1

2}, Andre F Carvalho³, Marco Solmi^{4

5

6

7

8}

¹ Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada. andrewlsmith@toh.ca.
² Department of Mental Health, The Ottawa Hospital, Ottawa, ON, Canada. andrewlsmith@toh.ca.
³ IMPACT (Innovation in Mental and Physical Health and Clinical Treatment) Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia.
⁴ Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada.
⁵ Department of Mental Health, The Ottawa Hospital, Ottawa, ON, Canada.
⁶ Ottawa Hospital Research Institute (OHRI) Clinical Epidemiology Program University of Ottawa, Ottawa, ON, Canada.
⁷ School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
⁸ Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.

No abstract available

Comment on

The serotonin theory of depression: a systematic umbrella review of the evidence.
Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA. Moncrieff J, et al. Mol Psychiatry. 2023 Aug;28(8):3243-3256. doi: 10.1038/s41380-022-01661-0. Epub 2022 Jul 20. Mol Psychiatry. 2023. PMID: 35854107 Free PMC article.

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