Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Feb 17;11(2):e01263.
doi: 10.14309/crj.0000000000001263. eCollection 2024 Feb.

Esophageal Adenocarcinoma Presenting as an Isolated Brain Lesion 6 Years After Treatment

Jeevan Murthy  1 , John Moise  1 , Kaitlyn Mi  2 , Sonikpreet Aulakh  1   3
Affiliations
Case Reports

Esophageal Adenocarcinoma Presenting as an Isolated Brain Lesion 6 Years After Treatment

Jeevan Murthy et al. ACG Case Rep J. .

Abstract

Intracranial metastasis is a rare sequela of esophageal adenocarcinoma (EAC), typically presenting within the first 2 years after primary tumor detection. Our patient is a 72-year-old man diagnosed with an EAC in 2015 and presented with recurrence of a distant solitary brain lesion approximately 6 years after the initial diagnosis. Histological diagnosis was confirmed as EAC with all relevant indicators. In addition, we used genomic profiling to detect biomarkers that can be useful in the future for therapies.

Keywords: brain metastasis; esophageal adenocarcinoma; gamma-knife radiation; gastroenterology; immunotherapy; neurooncology; next-generation sequencing.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Preop imaging of L parietal lobe mass. (A) T1 axial 1 GD, (B) T2 FLAIR, and (C) T1 OLEA. FLAIR, fluid-attenuated inversion recovery.
Figure 2.
Figure 2.
Postop imaging of L parietal lobe mass. (A) T1 axial 1 GD, (B) T2 FLAIR, and (C) T1 OLEA. FLAIR, fluid-attenuated inversion recovery.
Figure 3.
Figure 3.
Histological staining of brain metastasis. (A) Hemolysin and eosin staining, (B) HER2-negative, (C) EBER ISH–negative, (D) MSH6-positive, (E) MSH2-positive, and (F) MLH1-positive. EBER, Epstein-Barr encoding region; ISH, in situ hybridization.
Figure 4.
Figure 4.
Disease recurrence in L cerebellar hemisphere. (A) T1 axial 1 GD, (B) T2 FLAIR, and (C) T1 OLEA. FLAIR, fluid-attenuated inversion recovery.
See this image and copyright information in PMC

References

    1. Arnold M, Soerjomataram I, Ferlay J, Forman D. Global incidence of oesophageal cancer by histological subtype in 2012. Gut. 2015;64(3):381–7. - PubMed
    1. Coleman HG, Xie SH, Lagergren J. The epidemiology of esophageal adenocarcinoma. Gastroenterology. 2018;154(2):390–405. - PubMed
    1. Shaheen O, Ghibour A, Alsaid B. Esophageal cancer metastases to unexpected sites: A systematic review. Gastroenterol Res Pract. 2017;2017:1657310. - PMC - PubMed
    1. Vanstraelen S, Depypere L, Moons J, et al. . How to handle brain tumors after esophagectomy with curative intent: A single center 20-year experience. Eur J Surg Oncol. 2023;49(9):106916. - PubMed
    1. Nobel TB, Dave N, Eljalby M, et al. . Incidence and risk factors for isolated esophageal cancer recurrence to the brain. Ann Thorac Surg. 2020;109(2):329–36. - PMC - PubMed

Publication types