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Review
. 2024 Feb 14:25:355-366.
doi: 10.1016/j.reth.2024.01.009. eCollection 2024 Mar.

Exosomes from preconditioned mesenchymal stem cells: Tissue repair and regeneration

Ruili Long  1 , Shuai Wang  1
Affiliations
Review

Exosomes from preconditioned mesenchymal stem cells: Tissue repair and regeneration

Ruili Long et al. Regen Ther. .

Abstract

As a prominent research area in tissue repair and regeneration, mesenchymal stem cells (MSCs) have garnered substantial attention for their potential in the treatment of various diseases. It is now widely recognized that the therapeutic effects of MSCs primarily occur through paracrine mechanisms. Among these mechanisms, exosomes play a crucial role by exerting a series of regulatory effects on surrounding cells and tissues. While exosomes have shown promise in treating various diseases, they do have some limitations, such as limited secretion, poor targeting, and single functionality. However, MSC preconditioning can enhance the production of exosomes, lead to more stable functionality and improve therapeutic effects. Moreover, exosomes could also serve as carriers for specific drugs or genes, enabling more precise treatments of diseases. This review summarizes the most recent literatures on how preconditioning of MSCs influences the regenerative potential of their exosomes in tissue repair and provides new insights into the therapeutic application of exosomes derived from MSCs.

Keywords: Exosomes; Extracellular vesicles; Mesenchymal stem cells; Preconditioning; Tissue repair and regeneration.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Therapeutic effects of exosomes derived from preconditioned MSCs in tissue repair and regeneration.
See this image and copyright information in PMC

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