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Review
. 2023 Dec 14;16(1):56-69.
doi: 10.1016/j.chmed.2023.09.006. eCollection 2024 Jan.

Hypoxia inducible factor-1α related mechanism and TCM intervention in process of early fracture healing

Wenxian Zhang  1 , Fusen Yang  2 , Qikai Yan  1   3 , Jiahui Li  2 , Xiaogang Zhang  1 , Yiwei Jiang  1 , Jianye Dai  2
Affiliations
Review

Hypoxia inducible factor-1α related mechanism and TCM intervention in process of early fracture healing

Wenxian Zhang et al. Chin Herb Med. .

Abstract

As a common clinical disease, fracture is often accompanied by pain, swelling, bleeding as well as other symptoms and has a high disability rate, even threatening life, seriously endangering patients' physical and psychological health and quality of life. Medical practitioners take many strategies for the treatment of fracture healing, including Traditional Chinese Medicine (TCM). In the early stage of fracture healing, the local fracture is often in a state of hypoxia, accompanied by the expression of hypoxia inducible factor-1α (HIF-1α), which is beneficial to wound healing. Through literature mining, we thought that hypoxia, HIF-1α and downstream factors affected the mechanism of fracture healing, as well as dominated this process. Therefore, we reviewed the local characteristics and related signaling pathways involved in the fracture healing process and summarized the intervention of TCM on these mechanisms, in order to inspirit the new strategy for fracture healing, as well as elaborate on the possible principles of TCM in treating fractures based on the HIF molecular mechanism.

Keywords: fracture healing; hypoxia; hypoxia inducible factor-1α; molecular mechanism; traditional chinese medicine.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Effect of hypoxia and HIF-1α on BMSCs during fracture healing, and intervention of TCMs on these signaling pathways.
Fig. 2
Fig. 2
Effect of hypoxia and HIF-1α on OB during fracture healing, and intervention of TCMs on these signaling pathways.
Fig. 3
Fig. 3
Effect of hypoxia and HIF-1α on OC during fracture healing, and intervention of TCMs on these signaling pathways.
Fig. 4
Fig. 4
Related mechanism of hypoxia and HIF-1α in process of early fracture healing, and intervention of TCMs on these signaling pathways.
See this image and copyright information in PMC

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