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. 2024 Jun 1;49(11):743-751.
doi: 10.1097/BRS.0000000000004957. Epub 2024 Feb 20.

Impact of Hip and Knee Osteoarthritis on Full Body Sagittal Alignment and Compensation for Sagittal Spinal Deformity

Mariah Balmaceno-Criss  1 , Renaud Lafage  2 , Daniel Alsoof  1 , Mohammad Daher  1 , David Kojo Hamilton  3 , Justin S Smith  4 , Robert K Eastlack  5 , Richard G Fessler  6 , Jeffrey L Gum  7 , Munish C Gupta  8 , Richard Hostin  9 , Khaled M Kebaish  10 , Eric O Klineberg  11 , Stephen J Lewis  12 , Breton G Line  13 , Pierce D Nunley  14 , Gregory M Mundis  5 , Peter G Passias  15 , Themistocles S Protopsaltis  15 , Thomas Buell  3 , Justin K Scheer  16 , Jeffrey P Mullin  17 , Alex Soroceanu  18 , Christopher P Ames  16 , Lawrence G Lenke  19 , Shay Bess  13 , Christopher I Shaffrey  20 , Frank J Schwab  2 , Virginie Lafage  2 , Douglas C Burton  21 , Bassel G Diebo  1 , Alan H Daniels  1 ; International Spine Study Group (ISSG)
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Impact of Hip and Knee Osteoarthritis on Full Body Sagittal Alignment and Compensation for Sagittal Spinal Deformity

Mariah Balmaceno-Criss et al. Spine (Phila Pa 1976). .

Abstract

Study design: Retrospective review of prospectively collected data.

Objective: To investigate the effect of lower extremity osteoarthritis on sagittal alignment and compensatory mechanisms in adult spinal deformity (ASD).

Background: Spine, hip, and knee pathologies often overlap in ASD patients. Limited data exists on how lower extremity osteoarthritis impacts sagittal alignment and compensatory mechanisms in ASD.

Patients and methods: In total, 527 preoperative ASD patients with full body radiographs were included. Patients were grouped by Kellgren-Lawrence grade of bilateral hips and knees and stratified by quartile of T1-Pelvic Angle (T1PA) severity into low-, mid-, high-, and severe-T1PA. Full-body alignment and compensation were compared across quartiles. Regression analysis examined the incremental impact of hip and knee osteoarthritis severity on compensation.

Results: The mean T1PA for low-, mid-, high-, and severe-T1PA groups was 7.3°, 19.5°, 27.8°, and 41.6°, respectively. Mid-T1PA patients with severe hip osteoarthritis had an increased sagittal vertical axis and global sagittal alignment ( P <0.001). Increasing hip osteoarthritis severity resulted in decreased pelvic tilt ( P =0.001) and sacrofemoral angle ( P <0.001), but increased knee flexion ( P =0.012). Regression analysis revealed that with increasing T1PA, pelvic tilt correlated inversely with hip osteoarthritis and positively with knee osteoarthritis ( r2 =0.812). Hip osteoarthritis decreased compensation through sacrofemoral angle (β-coefficient=-0.206). Knee and hip osteoarthritis contributed to greater knee flexion (β-coefficients=0.215, 0.101; respectively). For pelvic shift, only hip osteoarthritis significantly contributed to the model (β-coefficient=0.100).

Conclusions: For the same magnitude of spinal deformity, increased hip osteoarthritis severity was associated with worse truncal and full body alignment with posterior translation of the pelvis. Patients with severe hip and knee osteoarthritis exhibited decreased hip extension and pelvic tilt but increased knee flexion. This examines sagittal alignment and compensation in ASD patients with hip and knee arthritis and may help delineate whether hip and knee flexion is due to spinal deformity compensation or lower extremity osteoarthritis.

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Conflict of interest statement

The International Spine Study Group reports the following: grants to the foundation from Medtronic, Globus, Stryker, SI Bone, Carlsmed. The remaining authors report no conflicts of interest.

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