Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb 20;7(1):20.
doi: 10.1186/s42155-024-00432-y.

Ultrasound (US)-guided percutaneous thrombin injection for stoma-site bleeding after PEG tube insertion: a case series and review of the literature

Affiliations

Ultrasound (US)-guided percutaneous thrombin injection for stoma-site bleeding after PEG tube insertion: a case series and review of the literature

Aws Alfahad et al. CVIR Endovasc. .

Abstract

Background: Post-gastrostomy bleeding sequelae are acknowledged, with reported approaches focusing on conservative measures or surgical repair. Nonetheless, Percutaneous Thrombin Injections (PTI) role in PEG-site-related bleeding remains underexplored. PTI under ultrasound guidance is an advocated management strategy for stoma-site bleeding following gastrostomy in high-risk patients, particularly those on direct oral anticoagulants.

Case presentation: This study presents three cases with multiple comorbidities who underwent PTI. Resulting in immediate resolution of bleeding, no systemic\local effect, and no reported complications or rebleeding after a 3-6-month follow-up.

Conclusion: The findings highlight the safety, direct complete resolution, and absence of sequelae associated with PTI, suggesting its potential as a promising technique in managing PEG stoma-related bleeding.

Keywords: Anticoagulants; GI bleeding; Interventional radiology; Percutaneous Thrombin Injections PTI; Thrombin; Ultrasound.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Illustration of PTI technique
Fig. 2
Fig. 2
Fluoroscopy image demonstrating the needle site
Fig. 3
Fig. 3
A non-enhanced CT scan of the PEG tube three days post-enjection, showcasing a patent ballon (green circle), a clear stomach wall devoid of necrosis or hematoma, and an absence of any bleeding (red arrow)
Fig. 4
Fig. 4
US post PTI revealing patent PEG balloon and no hemorrhage

References

    1. Umerah Co, Momodu II. Anticoagulation. In: StatPearls. Treasure Island: StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560651/. [Updated 2023 Jul 17].
    1. Mackman N, Tilley RE, Key NS. Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. Arterioscler Thromb Vasc Biol. 2007;27(8):1687–1693. doi: 10.1161/ATVBAHA.107.141911. - DOI - PubMed
    1. Zeballos-Palacios CL, Hargraves IG, Noseworthy PA, Branda ME, Kunneman M, Burnett B, Gionfriddo MR, McLeod CJ, Gorr H, Brito JP, Montori VM, Shared Decision Making for Atrial Fibrillation (SDM4AFib) Trial Investigators Developing a conversation aid to support shared decision making: reflections on designing anticoagulation choice. Mayo Clin Proc. 2019;94(4):686–696. doi: 10.1016/j.mayocp.2018.08.030. - DOI - PMC - PubMed
    1. Shoeb M, Fang MC. Assessing bleeding risk in patients taking anticoagulants. J Thromb Thrombolysis. 2013;35(3):312–319. doi: 10.1007/s11239-013-0899-7. - DOI - PMC - PubMed
    1. Fang MC, Go AS, Chang Y, Hylek EM, Henault LE, Jensvold NG, et al. Death and disability from warfarin-associated intracranial and extracranial hemorrhages. Am J Med. 2007;120:700–705. doi: 10.1016/j.amjmed.2006.07.034. - DOI - PMC - PubMed

LinkOut - more resources